Masitinib
Masitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mast/stem cell growth factor receptor Kit. In addition, it is known to target platelet-derived growth factor receptor alpha and platelet-derived growth factor receptor beta.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | 2 | 3 | — | — | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 3 | 1 | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | 2 | — | — | 3 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | 2 | — | — | 3 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | 2 | — | — | 3 |
| Multiple myeloma | D009101 | C90.0 | — | 1 | 1 | — | — | 2 | |
| Systemic mastocytosis | D034721 | C96.21 | — | — | 2 | — | — | 2 | |
| Colorectal neoplasms | D015179 | — | 1 | 2 | — | — | 2 | ||
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | 2 | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mastocytosis | D008415 | D47.09 | — | 3 | — | — | — | 3 | |
| Covid-19 | D000086382 | U07.1 | — | 2 | — | — | — | 2 | |
| Sars-cov-2 | D000086402 | — | 1 | — | — | — | 1 | ||
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MASITINIB |
| INN | masitinib |
| Description | Masitinib is a member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor. It has a role as a tyrosine kinase inhibitor, an antineoplastic agent and an antirheumatic drug. It is a N-alkylpiperazine, a member of 1,3-thiazoles, a member of pyridines and a member of benzamides. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 |
Identifiers
| PDB | 7JU7 |
| CAS-ID | 790299-79-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1908391 |
| ChEBI ID | 63450 |
| PubChem CID | 10074640 |
| DrugBank | DB11526 |
| UNII ID | M59NC4E26P (ChemIDplus, GSRS) |
Target
Agency Approved
KIT
KIT
Organism
Homo sapiens
Gene name
KIT
Gene synonyms
SCFR
NCBI Gene ID
Protein name
mast/stem cell growth factor receptor Kit
Protein synonyms
c-Kit protooncogene, CD117, p145 c-kit, PBT, Piebald trait protein, Proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Uniprot ID
Mouse ortholog
Kit (16590)
mast/stem cell growth factor receptor Kit (Q8C8K9)
Alternate
PDGFRA
PDGFRA
PDGFRB
PDGFRB
Organism
Homo sapiens
Gene name
PDGFRA
Gene synonyms
PDGFR2, RHEPDGFRA
NCBI Gene ID
Protein name
platelet-derived growth factor receptor alpha
Protein synonyms
Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, PDGF-R-alpha, PDGFR-2, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, platelet-derived growth factor receptor, alpha polypeptide
Uniprot ID
Mouse ortholog
Pdgfra (18595)
platelet-derived growth factor receptor alpha (Q8C4N3)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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