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Masoprocol
Actinex (masoprocol) is a small molecule pharmaceutical. Masoprocol was first approved as Actinex on 1992-09-04. It is used to treat keratosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Masoprocol
Tradename
Company
Number
Date
Products
ACTINEXUniversity Arizona Cancer CenterN-019940 DISCN1992-09-04
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
keratosis—D007642—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX10: Masoprocol
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tinea pedisD014008EFO_0007512B35.3—1—2—3
Tinea crurisD000084002B35.6———2—2
TineaD014005EFO_0007510B35.4———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OnychomycosisD014009B35.121———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMASOPROCOL
INNmasoprocol
Description
Masoprocol is the meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. It has a role as an antineoplastic agent, a lipoxygenase inhibitor, a hypoglycemic agent and a metabolite.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Identifiers
PDB—
CAS-ID500-38-9
RxCUI227239
ChEMBL IDCHEMBL313972
ChEBI ID73468
PubChem CID71398
DrugBankDB00179
UNII ID7BO8G1BYQU (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 292 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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41 adverse events reported
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