Mavoglurant
Mavoglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 8 | — | — | — | 8 |
| Dyskinesias | D020820 | G24 | — | 5 | — | — | — | 5 | |
| Parkinsonian disorders | D020734 | HP_0001300 | — | 3 | — | — | — | 3 | |
| Movement disorders | D009069 | EFO_0004280 | G25 | — | 3 | — | — | — | 3 |
| Cocaine-related disorders | D019970 | F14 | 1 | 1 | — | — | — | 2 | |
| Drug-induced dyskinesia | D004409 | EFO_1000904 | — | 1 | — | — | — | 1 | |
| Huntington disease | D006816 | G10 | — | 1 | — | — | — | 1 | |
| Chorea | D002819 | EFO_0004152 | G25.5 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | 1 | — | — | — | — | 1 | ||
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | 1 | — | — | — | — | 1 |
| Alcohol drinking | D000428 | EFO_0004329 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MAVOGLURANT |
| INN | mavoglurant |
| Description | Mavoglurant (developmental code name AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome and other conditions which has been discontinued. It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGluR5).
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| Classification | Small molecule |
| Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)N1CC[C@@H]2[C@H]1CCC[C@@]2(O)C#Cc1cccc(C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 543906-09-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3087515 |
| ChEBI ID | — |
| PubChem CID | 9926832 |
| DrugBank | DB13004 |
| UNII ID | GT0I9SV4F6 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 309 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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