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Mefenamic acid
Ponstel (mefenamic acid) is a small molecule pharmaceutical. Mefenamic acid was first approved as Ponstel on 1982-01-01. It is used to treat dysmenorrhea, fever, menorrhagia, and premenstrual syndrome in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target transient receptor potential cation channel subfamily M member 3, potassium voltage-gated channel subfamily KQT member 1, and aldo-keto reductase family 1 member C3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Ponstel (generic drugs available since 2010-11-19)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mefenamic acid
Tradename
Company
Number
Date
Products
PONSTELAvion PharmaceuticalsN-015034 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
mefenamic acidANDA2023-04-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dysmenorrheaHP_0100607D004412N94.6
feverHP_0001945D005334R50.9
menorrhagiaHP_0000132D008595N92.0
premenstrual syndrome—D011293N94.3
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AG: Fenamates, antiinflammatory and antirheumatic drugs
— M01AG01: Mefenamic acid
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11612—110
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ParturitionD036801————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMEFENAMIC ACID
INNmefenamic acid
Description
Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. It has a role as an analgesic, an antirheumatic drug, a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant and a xenobiotic. It is an aminobenzoic acid and a secondary amino compound.
Classification
Small molecule
Drug classanti-inflammatory agents (anthranilic acid derivatives) and their salts or esters
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(Nc2ccccc2C(=O)O)c1C
Identifiers
PDB3R43
CAS-ID61-68-7
RxCUI6693
ChEMBL IDCHEMBL686
ChEBI ID6717
PubChem CID4044
DrugBankDB00784
UNII ID367589PJ2C (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
5743
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Q16876
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
TRPM3
TRPM3
KCNQ1
KCNQ1
AKR1C3
AKR1C3
Organism
Homo sapiens
Gene name
TRPM3
Gene synonyms
KIAA1616, LTRPC3
NCBI Gene ID
80036
Protein name
transient receptor potential cation channel subfamily M member 3
Protein synonyms
Long transient receptor potential channel 3, LTrpC-3, LTrpC3, Melastatin-2, MLSN2
Uniprot ID
Q9HCF6
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Mefenamic acid
Adverse Events
Top Adverse Reactions
0 adverse events reported
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