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Menthol
Salonpas (menthol) is a small molecule pharmaceutical. Menthol was first approved as Salonpas on 2008-02-20. It is used to treat pain and skin diseases in the USA. The pharmaceutical is active against transient receptor potential cation channel subfamily M member 8, alpha-1A adrenergic receptor, and alpha-2A adrenergic receptor. In addition, it is known to target transient receptor potential cation channel subfamily A member 1, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 2C, transient receptor potential cation channel subfamily V member 3, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename
Company
Number
Date
Products
SALONPASHISAMITSU PHARM CON-022029 OTC2008-02-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
essentials OTC monograph not final2018-12-21
kofalOTC monograph not final2023-06-14
salonpasANDA2022-12-28
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
skin diseases—D012871L00-L99
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Menthol / Methyl Salicylate, Salonpas, Hisamitsu Pharm Co
88096152030-01-03DP
92331842027-08-01DP
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
174 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_00005456726232484
Female infertilityD007247EFO_0008560N972—74619
Polycystic ovary syndromeD011085EFO_0000660E28.21—34210
Fertilization in vitroD005307——16310
Ovulation inductionD010062—441110
HypogonadismD007006E23.0—11316
Kallmann syndromeD017436Orphanet_478E23.0—1—315
AnovulationD000858——2215
Intracytoplasmic sperm injectionsD020554———4—4
Assisted reproductive techniquesD027724——1113
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.11—1—46
Oocyte donationD018587——1—12
Embryo transferD004624——1——1
Male infertilityD007248EFO_0004248N46—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FertilizationD005306—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Area under curveD0195401————1
PharmacokineticsD0105991————1
AbsorptionD0000421————1
Ovarian neoplasmsD010051EFO_0003893C561————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FertilityD005298————22
Primary ovarian insufficiencyD016649EFO_0004266E28.3————22
ThalassemiaD013789EFO_1001996D56————11
ReproductionD012098————11
Pregnancy outcomeD011256————11
EndometriosisD004715EFO_0001065N80————11
GalactosemiasD005693E74.21————11
Female genital diseasesD005831EFO_0009549N85————11
Ovarian hyperstimulation syndromeD016471————11
Oxidative stressD018384EFO_1001905————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMENTHOL
INNracementhol
Description
(-)-menthol is a p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. It has a role as an antipruritic drug, an antitussive and an antispasmodic drug. It is an enantiomer of a (+)-menthol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1CCC(C(C)C)C(O)C1
Identifiers
PDB—
CAS-ID2216-51-5
RxCUI236388
ChEMBL IDCHEMBL256087
ChEBI ID25187
PubChem CID16666
DrugBankDB00825
UNII IDYS08XHA860 (ChemIDplus, GSRS)
Target
Agency Approved
TRPM8
TRPM8
ADRA1A
ADRA1A
ADRA2A
ADRA2A
Organism
Homo sapiens
Gene name
TRPM8
Gene synonyms
LTRPC6, TRPP8
NCBI Gene ID
79054
Protein name
transient receptor potential cation channel subfamily M member 8
Protein synonyms
Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, transient receptor potential subfamily M member 8, Trp-p8, TRPM8 cationic channel
Uniprot ID
Q9BVK1
Mouse ortholog
Trpm8 (171382)
transient receptor potential cation channel subfamily M member 8 (Q8R4D5)
Alternate
TRPA1
TRPA1
ADRA2B
ADRA2B
HTR1B
HTR1B
HTR1D
HTR1D
ADRA1B
ADRA1B
HTR2C
HTR2C
TRPV3
TRPV3
ADRA2C
ADRA2C
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
8989
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
O75762
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 14,430 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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990 adverse events reported
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