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Mesoridazine
Serentil (mesoridazine) is a small molecule pharmaceutical. Mesoridazine was first approved as Serentil on 1982-01-01. It is used to treat alcoholism, psychotic disorders, and schizophrenia in the USA. It is known to target D(2) dopamine receptor, D(3) dopamine receptor, D(1A) dopamine receptor, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 2A, and 5-hydroxytryptamine receptor 1A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mesoridazine besylate
Tradename
Company
Number
Date
Products
SERENTILNovartisN-016774 DISCN1982-01-01
4 products
SERENTILNovartisN-016775 DISCN1982-01-01
1 products
SERENTILNovartisN-016997 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alcoholismEFO_0003829D000437F10.1
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AC: Phenothiazines with piperidine structure, antipsychotics
— N05AC03: Mesoridazine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMESORIDAZINE
INNmesoridazine
Description
Mesoridazine is a phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group. It has a role as a dopaminergic antagonist and a first generation antipsychotic. It is a member of phenothiazines, a sulfoxide and a tertiary amino compound.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21
Identifiers
PDB—
CAS-ID5588-33-0
RxCUI6779
ChEMBL IDCHEMBL1088
ChEBI ID6780
PubChem CID4078
DrugBankDB00933
UNII ID5XE4NWM740 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DRD2
DRD2
DRD3
DRD3
DRD1
DRD1
HTR2C
HTR2C
HTR2A
HTR2A
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 341 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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