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Methacholine
Provocholine (methacholine) is a small molecule pharmaceutical. Methacholine was first approved as Provocholine on 1986-10-31. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Provocholine
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methacholine chloride
Tradename
Company
Number
Date
Products
PROVOCHOLINEMethapharmN-019193 RX1986-10-31
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
provocholineNew Drug Application2020-12-11
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX03: Methacholine
HCPCS
Code
Description
J7674
Methacholine chloride administered as inhalation solution through a nebulizer, per 1 mg
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pre-eclampsiaD011225EFO_0000668O14——1—12
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I95—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHACHOLINE
INNmethacholine chloride
Description
Methacholine is a quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis. It has a role as a muscarinic agonist, a bronchoconstrictor agent, an epitope, a cholinergic agonist and a vasodilator agent. It is a quaternary ammonium ion and an acetate ester.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)OC(C)C[N+](C)(C)C
Identifiers
PDB—
CAS-ID55-92-5
RxCUI155080
ChEMBL IDCHEMBL978
ChEBI ID6804
PubChem CID1993
DrugBankDB06709
UNII ID0W5ETF9M2K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM4
Gene synonyms
NCBI Gene ID
1132
Protein name
muscarinic acetylcholine receptor M4
Protein synonyms
acetylcholine receptor, muscarinic 4
Uniprot ID
Q4VBK7
Mouse ortholog
Chrm4 (12672)
muscarinic acetylcholine receptor M4 (Q64056)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,699 documents
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Safety
Black-box Warning
Black-box warning for: Provocholine
Adverse Events
Top Adverse Reactions
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1,446 adverse events reported
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