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Methacholine chloride
Provocholine (methacholine chloride) is a small molecule pharmaceutical. Methacholine chloride was first approved as Provocholine on 1986-10-31. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M5.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Provocholine
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methacholine chloride
Tradename
Company
Number
Date
Products
PROVOCHOLINEMethapharmN-019193 RX1986-10-31
1 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
provocholine provocholine inhalation solutionNew Drug Application2022-07-12
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX03: Methacholine
HCPCS
Code
Description
J7674
Methacholine chloride administered as inhalation solution through a nebulizer, per 1 mg
Clinical
Clinical Trials
44 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J4511551931
CoughD003371HP_0012735R05———112
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E131————1
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bronchial hyperreactivityD016535————44
HypersensitivityD006967EFO_0003785T78.40————22
Exercise-induced asthmaD001250J45.990————22
Allergic rhinitisD065631J30.9————11
Hypophosphatemic ricketsD063730E83.31————11
DyspneaD004417HP_0002094R06.0————11
HivD006678O98.7————11
AdiposityD050154————11
Respiratory hypersensitivityD012130————11
Gastroesophageal refluxD005764EFO_0003948K21————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHACHOLINE CHLORIDE
INNmethacholine chloride
Description
Methacholine is a quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis. It has a role as a muscarinic agonist, a bronchoconstrictor agent, an epitope, a cholinergic agonist and a vasodilator agent. It is a quaternary ammonium ion and an acetate ester.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)OC(C)C[N+](C)(C)C.[Cl-]
Identifiers
PDB—
CAS-ID55-92-5
RxCUI155080
ChEMBL IDCHEMBL1200764
ChEBI ID50142
PubChem CID1993
DrugBankDB06709
UNII ID0W5ETF9M2K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM2
CHRM2
CHRM1
CHRM1
CHRM5
CHRM5
Organism
Homo sapiens
Gene name
CHRM4
Gene synonyms
NCBI Gene ID
1132
Protein name
muscarinic acetylcholine receptor M4
Protein synonyms
acetylcholine receptor, muscarinic 4
Uniprot ID
Q4VBK7
Mouse ortholog
Chrm4 (12672)
muscarinic acetylcholine receptor M4 (Q64056)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,053 documents
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Safety
Black-box Warning
Black-box warning for: Provocholine provocholine inhalation solution
Adverse Events
Top Adverse Reactions
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33 adverse events reported
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