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Methimazole
Tapazole (methimazole) is a small molecule pharmaceutical. Methimazole was first approved as Tapazole on 1982-01-01. It is used to treat goiter and thyroid crisis in the USA. The pharmaceutical is active against thyroid peroxidase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methimazole
Tradename
Company
Number
Date
Products
TAPAZOLEKing PharmaceuticalsN-007517 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
methimazoleANDA2023-06-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
goiterEFO_0004283D006042E04.9
thyroid crisisEFO_1001212D013958E05.5
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H03: Thyroid therapy drugs
— H03B: Antithyroid preparations
— H03BB: Sulfur-containing imidazole derivatives, antithyroid preparations
— H03BB02: Thiamazole
— H03BB52: Thiamazole, combinations
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHIMAZOLE
INNthiamazole
Description
Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cn1ccnc1S
Identifiers
PDB5GSN
CAS-ID60-56-0
RxCUI6835
ChEMBL IDCHEMBL1515
ChEBI ID50673
PubChem CID1349907
DrugBankDB00763
UNII ID554Z48XN5E (ChemIDplus, GSRS)
Target
Agency Approved
TPO
TPO
Organism
Homo sapiens
Gene name
TPO
Gene synonyms
NCBI Gene ID
7173
Protein name
thyroid peroxidase
Protein synonyms
thyroid microsomal antigen, thyroperoxidase
Uniprot ID
Q8TCI9
Mouse ortholog
Tpo (22018)
thyroid peroxidase (Q8C8B1)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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