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Methoxamine
Vasoxyl (methoxamine) is a small molecule pharmaceutical. Methoxamine was first approved as Vasoxyl on 1982-01-01. The pharmaceutical is active against alpha-1A adrenergic receptor. In addition, it is known to target alpha-1D adrenergic receptor and alpha-1B adrenergic receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methoxamine hydrochloride
Tradename
Company
Number
Date
Products
VASOXYLGSKN-006772 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA10: Methoxamine
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.9———213
Bipolar disorderD001714EFO_0000289F30.9———112
Atrial fibrillationD001281EFO_0000275I48.0———1—1
Atrial flutterD001282EFO_0003911———1—1
Depressive disorderD003866EFO_1002014F32.A———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Electroconvulsive therapyD0045651————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I95————11
AnesthesiaD000758————11
Major depressive disorderD003865EFO_0003761F22————11
Anesthesia recovery periodD000762————11
OrientationD009949————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHOXAMINE
INNmethoxamine
Description
Methoxamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. It has a role as an antihypotensive agent and an alpha-adrenergic agonist.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(OC)c(C(O)C(C)N)c1
Identifiers
PDB—
CAS-ID390-28-3
RxCUI6853
ChEMBL IDCHEMBL524
ChEBI ID6839
PubChem CID6082
DrugBankDB00723
UNII IDHUQ1KC1YLI (ChemIDplus, GSRS)
Target
Agency Approved
ADRA1A
ADRA1A
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
148
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Q9UD67
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
ADRA1D
ADRA1D
ADRA1B
ADRA1B
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
146
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Q9NPY0
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,038 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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174 adverse events reported
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