Methoxyflurane
Methoxyflurane is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute pain | D059787 | R52 | — | — | 4 | 6 | 1 | 11 | |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 2 | 2 | 4 |
| Wounds and injuries | D014947 | T14.8 | — | — | — | 2 | — | 2 | |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | — | 1 | — | 1 |
| Hypovolemia | D020896 | HP_0011106 | E86 | — | — | — | 1 | — | 1 |
| Pain measurement | D010147 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| St elevation myocardial infarction | D000072657 | — | — | 1 | — | — | 1 | ||
| Neoplasms | D009369 | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Traumatic brain injuries | D000070642 | S06 | — | — | — | — | 1 | 1 | |
| Shoulder dislocation | D012783 | S43.0 | — | — | — | — | 1 | 1 | |
| Pain management | D059408 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | METHOXYFLURANE |
| INN | methoxyflurane |
| Description | Methoxyflurane is an ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl. It has a role as an inhalation anaesthetic, a non-narcotic analgesic, a hepatotoxic agent and a nephrotoxic agent. It is an organofluorine compound, an organochlorine compound and an ether. |
| Classification | Small molecule |
| Drug class | general inhalation anesthetics (halogenated alkane derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COC(F)(F)C(Cl)Cl |
Identifiers
| PDB | — |
| CAS-ID | 76-38-0 |
| RxCUI | 6857 |
| ChEMBL ID | CHEMBL1341 |
| ChEBI ID | 6843 |
| PubChem CID | 4116 |
| DrugBank | DB01028 |
| UNII ID | 30905R8O7B (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
Identifier | Target mutation | Effect | Evaluation | Status |
|---|---|---|---|---|
| VCV000575733 | CACNA1S, 520C>T, Arg174Trp | drug response | 2021-03-24 | 1A |
| VCV000017626 | CACNA1S, 3257G>A, Arg1086His | drug response | 2021-03-24 | 1A |
| VCV000012984 | RYR1, 14545G>A, Val4849Ile | drug response | 2021-03-24 | 1A |
| VCV000012972 | RYR1, 7373G>A, Arg2458His | drug response | 2021-03-24 | 1A |
Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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27 adverse events reported
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