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Methyldopa
Aldoclor, Aldomet, Aldoril (methyldopa) is a small molecule pharmaceutical. Methyldopa was first approved as Aldoclor-150 on 1982-01-01. It is used to treat hypertension in the USA. It is known to target aromatic-L-amino-acid decarboxylase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorothiazide
+
Methyldopa
Tradename
Company
Number
Date
Products
ALDOCLOR-150Merck KGaAN-016016 DISCN1982-01-01
1 products
ALDOCLOR-250Merck KGaAN-016016 DISCN1982-01-01
1 products
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Hydrochlorothiazide
+
Methyldopa
Tradename
Company
Number
Date
Products
ALDORIL 15Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL 25Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL D30Merck KGaAN-013402 DISCN1982-01-01
1 products
ALDORIL D50Merck KGaAN-013402 DISCN1982-01-01
1 products
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Methyldopa
Tradename
Company
Number
Date
Products
METHYLDOPAChartwell PharmaceuticalsN-018934 RX1984-06-29
2 products, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
methyldopaNew Drug Application2023-01-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AB: Methyldopa, centrally acting adntiadrenergic agents
— C02AB01: Methyldopa (levorotatory)
— C02AB02: Methyldopa (racemic)
— C02L: Antihypertensives and diuretics in combination
— C02LB: Methyldopa and diuretics in combination
— C02LB01: Methyldopa (levorotatory) and diuretics
HCPCS
Code
Description
J0210
Injection, methyldopate hcl, up to 250 mg
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoarthritisD010003EFO_0002506M15-M19———112
Femoral fracturesD005264S72———1—1
OsteonecrosisD010020EFO_0004259M87———1—1
Congenital hip dislocationD006618HP_0001385Q65.2———1—1
Slipped capital femoral epiphysesD060048———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ArthritisD001168EFO_0005856M05-M14————11
Rheumatic diseasesD012216M79.0————11
Joint diseasesD007592HP_0003040M12.9————11
Musculoskeletal diseasesD009140————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHYLDOPA
INNmethyldopa
Description
Alpha-methyl-L-dopa is a derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. It has a role as a hapten, an antihypertensive agent, an alpha-adrenergic agonist, a peripheral nervous system drug and a sympatholytic agent. It is a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid.
Classification
Small molecule
Drug classdopamine receptor agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O
Identifiers
PDB—
CAS-ID555-30-6
RxCUI1545996
ChEMBL IDCHEMBL459
ChEBI ID61058
PubChem CID38853
DrugBankDB00968
UNII IDM4R0H12F6M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DDC
DDC
Organism
Homo sapiens
Gene name
DDC
Gene synonyms
AADC
NCBI Gene ID
1644
Protein name
aromatic-L-amino-acid decarboxylase
Protein synonyms
DDC, DOPA decarboxylase, dopa decarboxylase (aromatic L-amino acid decarboxylase)
Uniprot ID
Q75MJ6
Mouse ortholog
Ddc (13195)
aromatic-L-amino-acid decarboxylase (O88533)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,835 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14 adverse events reported
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