Methyltestosterone
Android, Metandren, Oreton, Testred, Virilon (methyltestosterone) is a small molecule pharmaceutical. Methyltestosterone was first approved as Metandren on 1982-01-01. It is used to treat breast neoplasms, delayed puberty, erectile dysfunction, and hypogonadism in the USA. The pharmaceutical is active against androgen receptor.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
| endocrine system diseases | D004700 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| esterified estrogens and methyltestosterone | unapproved drug other | 2023-04-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| breast neoplasms | EFO_0003869 | D001943 | C50 |
| delayed puberty | HP_0000823 | D011628 | E30.0 |
| erectile dysfunction | EFO_0004234 | D007172 | F52.21 |
| hypogonadism | HP_0000815 | D007006 | E23.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03B: Androgens
— G03BA: 3-oxoandrosten (4) derivatives
— G03BA02: Methyltestosterone
— G03E: Androgens and female sex hormones in combination
— G03EA: Androgens and estrogens
— G03EA01: Methyltestosterone and estrogen
— G03EK: Androgens and female sex hormones in combination with other drugs
— G03EK01: Methyltestosterone
HCPCS
No data
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | 2 | — | 3 | 1 | 6 |
| Pregnancy-induced hypertension | D046110 | O13 | — | — | — | 2 | 1 | 3 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | 1 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | — | — | 1 | 2 |
| Proteinuria | D011507 | HP_0000093 | R80 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Orthostatic intolerance | D054971 | 2 | — | — | — | — | 2 | ||
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | I95.1 | 1 | — | — | — | — | 1 | |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Postural orthostatic tachycardia syndrome | D054972 | G90.A | 1 | — | — | — | — | 1 | |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | METHYLTESTOSTERONE |
| INN | methyltestosterone |
| Description | Methyltestosterone is a 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position. It has a role as an antineoplastic agent, an anabolic agent and an androgen. It is a 3-oxo-Delta(4) steroid, a 17beta-hydroxy steroid and an enone. It is functionally related to a testosterone. |
| Classification | Small molecule |
| Drug class | steroids (androgens, anabolics); antiandrogens |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C |
Identifiers
| PDB | — |
| CAS-ID | 58-18-4 |
| RxCUI | 6904 |
| ChEMBL ID | CHEMBL1395 |
| ChEBI ID | 27436 |
| PubChem CID | 6010 |
| DrugBank | DB06710 |
| UNII ID | V9EFU16ZIF (ChemIDplus, GSRS) |
Target
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,542 documents
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Safety
Black-box Warning
Black-box warning for: Esterified estrogens and methyltestosterone
Adverse Events
Top Adverse Reactions
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2,611 adverse events reported
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