Metoprolol
Dutoprol, Kapspargo, Lopressidone, Lopressor, Toprol-xl (metoprolol) is a small molecule pharmaceutical. Metoprolol was first approved as Lopressor on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Trade Name
FDA
EMA
Kapspargo, Lopressor, Toprol-xl (generic drugs available since 1993-12-21, discontinued: Lopressor)
CombinationsLopressor (generic drugs available since 1993-12-21, discontinued: Dutoprol, Lopressidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorthalidone
+
Metoprolol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSIDONE | Novartis | N-019451 DISCN | 1987-12-31 | 2 products |
Hide discontinued
Hydrochlorothiazide
+
Metoprolol succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUTOPROL | Concordia Laboratories | N-021956 DISCN | 2006-08-28 | 3 products, RLD |
Hide discontinued
Hydrochlorothiazide
+
Metoprolol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSOR HCT | Validus Pharmaceuticals | N-018303 RX | 1984-12-31 | 1 products, RLD |
Show 1 discontinued
Metoprolol fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSOR | Novartis | N-019786 DISCN | 1989-12-27 | 4 products |
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Metoprolol succinate
Metoprolol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPRESSOR | Validus Pharmaceuticals | N-017963 RX | 1982-01-01 | 2 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| kapspargo | New Drug Application | 2020-07-15 |
| lopressor | New Drug Application | 2021-01-26 |
| metoprolol tartrate | ANDA | 2023-06-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| angina pectoris | EFO_0003913 | D000787 | I20 |
| atrial fibrillation | EFO_0000275 | D001281 | I48.0 |
| atrial flutter | EFO_0003911 | D001282 | — |
| heart failure | EFO_0003144 | D006333 | I50 |
| hypertension | EFO_0000537 | D006973 | I10 |
| myocardial infarction | EFO_0000612 | D009203 | I21 |
| supraventricular tachycardia | HP_0004755 | D013617 | I47.1 |
| ventricular fibrillation | EFO_0004287 | D014693 | I49.01 |
| ventricular tachycardia | — | D017180 | I47.2 |
Agency Specific
FDA
EMA
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB02: Metoprolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB02: Metoprolol and thiazides
— C07BB52: Metoprolol and thiazides, combinations
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB02: Metoprolol and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB02: Metoprolol and felodipine
— C07FB13: Metoprolol and amlodipine
— C07FX: Beta blocking agents, other combinations
— C07FX03: Metoprolol and acetylsalicylic acid
— C07FX05: Metoprolol and ivabradine
HCPCS
No data
Clinical
Clinical Trials
212 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 3 | 6 | 14 | 26 | 10 | 55 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 2 | 3 | 5 | 7 | 17 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | 4 | 4 | 6 | 15 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | 1 | — | 2 | — | 6 |
| Coronary artery disease | D003324 | I25.1 | — | — | — | 4 | 2 | 6 | |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 1 | 4 | — | 5 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | 1 | — | — | 3 | — | 4 | |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 1 | — | 2 | 1 | 4 | |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 1 | 1 | — | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 1 | 1 | 1 | — | 4 |
Show 40 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventricular tachycardia | D017180 | I47.2 | — | 2 | 1 | — | 1 | 3 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | — | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | 1 | — | 1 | — | — | 2 | |
| Mitral valve insufficiency | D008944 | HP_0001653 | 1 | 1 | 1 | — | — | 2 | |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 1 | 1 | — | — | 2 |
| Lung neoplasms | D008175 | C34.90 | — | — | 1 | — | — | 1 | |
| Chronic renal insufficiency | D051436 | N18 | — | — | 1 | — | — | 1 | |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | — | 1 | 1 | — | — | 1 |
| Recurrence | D012008 | — | 1 | 1 | — | — | 1 | ||
| Alpha-thalassemia | D017085 | Orphanet_846 | D56.0 | — | 1 | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 17 | 1 | — | — | — | 18 | ||
| Neoplasms | D009369 | C80 | 2 | 1 | — | — | — | 2 | |
| Diastolic heart failure | D054144 | EFO_1000899 | I50.30 | — | 1 | — | — | 1 | 2 |
| Cognitive dysfunction | D060825 | G31.84 | — | 1 | — | — | — | 1 | |
| Aging | D000375 | GO_0007568 | R41.81 | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | 1 | 1 | — | — | — | 1 | ||
| Postural orthostatic tachycardia syndrome | D054972 | G90.A | — | 1 | — | — | — | 1 | |
| Macular edema | D008269 | 1 | 1 | — | — | — | 1 | ||
| Multiple trauma | D009104 | T07 | — | 1 | — | — | — | 1 | |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | 1 | — | — | — | 1 | 2 | ||
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | — | — | — | — | 2 |
| Fasting | D005215 | EFO_0002756 | 2 | — | — | — | — | 2 | |
| Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | — | — | — | 1 | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | 1 | — | — | — | — | 1 |
| Stable angina | D060050 | I20.8 | 1 | — | — | — | — | 1 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | — | 1 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | 1 | — | — | — | — | 1 | ||
| Covid-19 | D000086382 | U07.1 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Percutaneous coronary intervention | D062645 | — | — | — | — | 2 | 2 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 2 | 2 |
| Coronary occlusion | D054059 | I21 | — | — | — | — | 1 | 1 | |
| Drug-eluting stents | D054855 | — | — | — | — | 1 | 1 | ||
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | — | — | 1 | 1 |
| Computed tomography angiography | D000072226 | — | — | — | — | 1 | 1 | ||
| Exercise test | D005080 | EFO_0004328 | — | — | — | — | 1 | 1 | |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | 1 |
Show 5 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | METOPROLOL |
| INN | metoprolol |
| Description | Metoprolol is a propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, a xenobiotic, an environmental contaminant and a geroprotector. It is a propanolamine, an aromatic ether, a secondary alcohol and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COCCc1ccc(OCC(O)CNC(C)C)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 51384-51-1 |
| RxCUI | 6918 |
| ChEMBL ID | CHEMBL13 |
| ChEBI ID | 6904 |
| PubChem CID | 4171 |
| DrugBank | DB00264 |
| UNII ID | GEB06NHM23 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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42,255 adverse events reported
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