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Mibefradil
Mibefradil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-dependent T-type calcium channel subunit alpha-1H, anoctamin-1, voltage-dependent L-type calcium channel subunit alpha-1C, cation channel sperm-associated protein 2, cation channel sperm-associated protein 4, voltage-dependent T-type calcium channel subunit alpha-1G, cation channel sperm-associated protein 1, cation channel sperm-associated protein 3, voltage-dependent T-type calcium channel subunit alpha-1I, voltage-dependent P/Q-type calcium channel subunit alpha-1A, voltage-dependent R-type calcium channel subunit alpha-1E, and cytochrome P450 3A4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CX: Other selective calcium channel blockers with mainly vascular effects in atc
— C08CX01: Mibefradil
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Central nervous system neoplasmsD0165431————1
GlioblastomaD005909EFO_00005151————1
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMIBEFRADIL
INNmibefradil
Description
Mibefradil is a member of tetralins. It has a role as a T-type calcium channel blocker.
Classification
Small molecule
Drug classvasodilators (undefined group): calcium channel blockers acting as vasodilators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
Identifiers
PDB6OO9
CAS-ID116644-53-2
RxCUI83213
ChEMBL IDCHEMBL45816
ChEBI ID6920
PubChem CID60663
DrugBankDB01388
UNII ID27B90X776A (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CACNA1H
CACNA1H
ANO1
ANO1
CACNA1C
CACNA1C
CATSPER2
CATSPER2
CATSPER4
CATSPER4
CACNA1G
CACNA1G
CATSPER1
CATSPER1
CATSPER3
CATSPER3
CACNA1I
CACNA1I
CACNA1A
CACNA1A
CACNA1E
CACNA1E
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
CACNA1H
Gene synonyms
NCBI Gene ID
8912
Protein name
voltage-dependent T-type calcium channel subunit alpha-1H
Protein synonyms
calcium channel, voltage-dependent, T type, alpha 1H subunit, calcium channel, voltage-dependent, T type, alpha 1Hb subunit, Low-voltage-activated calcium channel alpha1 3.2 subunit, low-voltage-activated calcium channel alpha13.2 subunit, voltage dependent t-type calcium channel alpha-1H subunit, voltage-gated calcium channel alpha subunit Cav3.2, voltage-gated calcium channel alpha subunit CavT.2, Voltage-gated calcium channel subunit alpha Cav3.2
Uniprot ID
O95180
Mouse ortholog
Cacna1h (58226)
voltage-dependent T-type calcium channel subunit alpha-1H (O88427)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,766 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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