Skip to content
Midodrine
Proamatine (midodrine) is a small molecule pharmaceutical. Midodrine was first approved as Proamatine on 1996-09-06. It is used to treat orthostatic hypotension and urinary incontinence in the USA.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Midodrine hydrochloride
Tradename
Company
Number
Date
Products
PROAMATINETakedaN-019815 DISCN1996-09-06
3 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
midodrine hydrochlorideANDA2023-04-14
proamatineNew Drug Application2010-05-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
orthostatic hypotension—D007024I95.1
urinary incontinenceHP_0000020D014549R32
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA17: Midodrine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameMIDODRINE
INNmidodrine
Description
Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a prodrug, an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It is a secondary alcohol, an amino acid amide and an aromatic ether. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+).
Classification
Small molecule
Drug classsympathomimetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(OC)c(C(O)CNC(=O)CN)c1
Identifiers
PDB—
CAS-ID42794-76-3
RxCUI6963
ChEMBL IDCHEMBL1201212
ChEBI ID6933
PubChem CID4195
DrugBankDB00211
UNII ID6YE7PBM15H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 1,989 documents
View more details
Safety
Black-box Warning
Black-box warning for: Midodrine hydrochloride, Proamatine
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
32 adverse events reported
View more details