Milnacipran
Savella (milnacipran) is a small molecule pharmaceutical. Milnacipran was first approved as Savella on 2009-01-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Savella
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Milnacipran hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SAVELLA | AbbVie | N-022256 RX | 2009-01-14 | 4 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| milnacipran hcl | ANDA | 2023-03-22 |
| milnacipran hcl | ANDA | 2023-03-22 |
| savella | New Drug Application | 2022-12-23 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| major depressive disorder | EFO_0003761 | D003865 | F22 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Orthostatic hypotension | D007024 | I95.1 | 5 | 5 | 2 | 7 | 1 | 18 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 4 | 2 | 1 | 5 | 10 |
| Ascites | D001201 | HP_0001541 | R18 | — | 1 | 2 | 1 | 4 | 7 |
| Hepatorenal syndrome | D006530 | K76.7 | — | 4 | 2 | 1 | 1 | 6 | |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | 2 | 1 | 3 | 6 |
| Septic shock | D012772 | A48.3 | — | — | 2 | 2 | — | 4 | |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 2 | — | 1 | — | 3 |
| Sepsis | D018805 | A41.9 | 1 | — | — | 2 | — | 3 | |
| Vasovagal syncope | D019462 | R55 | — | — | 1 | 1 | — | 2 | |
| Critical illness | D016638 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | 4 | 2 | — | — | 5 | |
| Orthostatic intolerance | D054971 | 1 | 1 | 1 | — | 2 | 4 | ||
| Blood pressure | D001794 | EFO_0004325 | 1 | 2 | 1 | — | — | 3 | |
| Autonomic dysreflexia | D020211 | EFO_1001762 | G90.4 | — | 2 | 1 | — | — | 2 |
| Cerebrovascular circulation | D002560 | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | 5 | 1 | — | — | 1 | 6 | ||
| Multiple system atrophy | D019578 | 4 | 1 | — | — | 1 | 5 | ||
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 1 | — | — | 1 | 2 |
| Fibrosis | D005355 | — | 1 | — | — | 1 | 2 | ||
| Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | 1 | — | — | — | 1 |
| Ischemic stroke | D000083242 | — | 1 | — | — | — | 1 | ||
| Cognition | D003071 | EFO_0003925 | — | 1 | — | — | — | 1 | |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | — | — | — | 1 | 3 |
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 | ||
| Hepatopulmonary syndrome | D020065 | EFO_1001346 | K76.81 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinsonian disorders | D020734 | HP_0001300 | — | — | — | — | 1 | 1 | |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | 1 | 1 | ||
| Only child | D009863 | — | — | — | — | 1 | 1 | ||
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 1 | 1 |
| Syncope | D013575 | HP_0001279 | G90.01 | — | — | — | — | 1 | 1 |
| Spinal anesthesia | D000775 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MILNACIPRAN |
| INN | milnacipran |
| Description | (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide is a member of acetamides. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=O)C1(c2ccccc2)CC1CN |
Identifiers
| PDB | — |
| CAS-ID | 92623-85-3 |
| RxCUI | 588250 |
| ChEMBL ID | CHEMBL259209 |
| ChEBI ID | — |
| PubChem CID | 65833 |
| DrugBank | DB04896 |
| UNII ID | G56VK1HF36 (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
No data
Variants
Clinical Variant
No data
Financial
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Savella - Warner Chilcott
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,912 documents
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Safety
Black-box Warning
Black-box warning for: Milnacipran hcl, Milnacipran hcl, Savella
Adverse Events
Top Adverse Reactions
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1,068 adverse events reported
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