Milvexian
Milvexian is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target plasma kallikrein, coagulation factor XI, and chymotrypsin-C.
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Therapeutic Areas
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Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | 1 | — | — | — | 1 | ||
| Replacement arthroplasty knee | D019645 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 10 | — | — | — | — | 10 | ||
| Thrombosis | D013927 | 9 | — | — | — | — | 9 | ||
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MILVEXIAN |
| INN | milvexian |
| Description | Milvexian is a factor XIa inhibitor which acts as an anticoagulant. It is taken by mouth. As of late 2021, it was under study for the prevention of blood clots in patients undergoing surgery.
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| Classification | Small molecule |
| Drug class | coagulation factor XIa inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1CCC[C@H](n2cnc(-c3cc(Cl)ccc3-n3cc(Cl)nn3)cc2=O)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 1802425-99-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4112929 |
| ChEBI ID | — |
| PubChem CID | 118277544 |
| DrugBank | DB16233 |
| UNII ID | 0W79NDQ608 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
KLKB1
KLKB1
F11
F11
CTRC
CTRC
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 52 documents
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Safety
Black-box Warning
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Adverse Events
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0 adverse events reported
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