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Minoxidil
Rogaine, Theroxidil (minoxidil) is a small molecule pharmaceutical. Minoxidil was first approved as Loniten on 1982-01-01. It is used to treat alopecia and malignant hypertension in the USA. It is known to target ATP-sensitive inward rectifier potassium channel 11, ATP-sensitive inward rectifier potassium channel 8, and prostacyclin synthase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Rogaine, Theroxidil (generic drugs available since 1987-03-03, discontinued: Loniten, Minodyl)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Minoxidil
Tradename
Company
Number
Date
Products
ROGAINE (FOR MEN)Johnson & JohnsonN-019501 OTC1996-02-09
1 products, RLD, RS
ROGAINE (FOR WOMEN)Johnson & JohnsonN-019501 OTC1996-02-09
1 products, RLD, RS
ROGAINE EXTRA STRENGTH (FOR MEN)Johnson & JohnsonN-020834 OTC1997-11-14
1 products, RLD, RS
WOMEN'S ROGAINEJohnson & JohnsonN-021812 OTC2014-02-28
1 products, RLD, RS
MEN'S ROGAINEJohnson & JohnsonN-021812 OTC2006-01-20
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
hers hair regrowth treatmentANDA2023-06-17
womens rogaine unscentedNew Drug Application2023-04-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alopeciaHP_0002293D000505L64
malignant hypertensionEFO_1001031D006974—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02D: Arteriolar smooth muscle, agents acting on
— C02DC: Pyrimidine derivatives acting on arteriolar smooth muscle
— C02DC01: Minoxidil
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX01: Minoxidil
HCPCS
Code
Description
S0139
Minoxidil, 10 mg
Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AlopeciaD000505HP_0002293L64512113733
Alopecia areataD000506EFO_0004192L63———112
HypotrichosisD007039———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Self-assessmentD01264711———1
Williams syndromeD018980Orphanet_904Q93.82—1———1
Ovarian neoplasmsD010051EFO_0003893C56—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fissure in anoD005401HP_0012390K60.2————11
HypertensionD006973EFO_0000537I10————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMINOXIDIL
INNminoxidil
Description
Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.
Classification
Small molecule
Drug classvasodilators (undefined group)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]
Identifiers
PDB3B6H
CAS-ID38304-91-5
RxCUI6984
ChEMBL IDCHEMBL802
ChEBI ID6942
PubChem CID4201
DrugBankDB00350
UNII ID5965120SH1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNJ11
KCNJ11
KCNJ8
KCNJ8
PTGIS
PTGIS
Organism
Homo sapiens
Gene name
KCNJ11
Gene synonyms
NCBI Gene ID
3767
Protein name
ATP-sensitive inward rectifier potassium channel 11
Protein synonyms
beta-cell inward rectifier subunit, IKATP, Inward rectifier K(+) channel Kir6.2, inwardly rectifing potassium channel subfamily J member 11, inwardly rectifying potassium channel KIR6.2, inwardly-rectifying potassium channel subfamily J member 11, potassium channel inwardly rectifing subfamily J member 11, Potassium channel, inwardly rectifying subfamily J member 11, potassium voltage-gated channel subfamily J member 11
Uniprot ID
Q8IW96
Mouse ortholog
Kcnj11 (16514)
ATP-sensitive inward rectifier potassium channel 11 (Q9QX21)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,688 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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201 adverse events reported
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