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Miridesap
Miridesap is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serum amyloid P-component.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AmyloidosisD000686EFO_1001875E8551———6
HivD006678O98.711———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMIRIDESAP
INNmiridesap
Description
CPHPC ((R)-1-{6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl}pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.
Classification
Small molecule
Drug classserum amyloid P (SAP) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)[C@H]1CCCN1C(=O)CCCCC(=O)N1CCC[C@@H]1C(=O)O
Identifiers
PDB4AVT
CAS-ID224624-80-0
RxCUI—
ChEMBL IDCHEMBL25263
ChEBI ID—
PubChem CID125516
DrugBankDB13087
UNII IDWO97N24A47 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
APCS
APCS
Organism
Homo sapiens
Gene name
APCS
Gene synonyms
PTX2
NCBI Gene ID
325
Protein name
serum amyloid P-component
Protein synonyms
9.5S alpha-1-glycoprotein, epididymis secretory sperm binding protein Li 92n, pentaxin-related, pentraxin-2, pentraxin-related
Uniprot ID
P02743
Mouse ortholog
Apcs (20219)
serum amyloid P-component (P12246)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 25 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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