Mocetinostat
Mocetinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 2, histone deacetylase 3, and histone deacetylase 1.
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SARS-CoV-2 Interaction
Commercial
Therapeutic Areas
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Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | D46 | 4 | 4 | — | — | — | 6 | |
Myeloid leukemia acute | D015470 | C92.0 | 1 | 3 | — | — | — | 3 | |
Hodgkin disease | D006689 | C81 | 1 | 3 | — | — | — | 3 | |
Neoplasms | D009369 | C80 | 3 | 2 | — | — | — | 3 | |
Non-hodgkin lymphoma | D008228 | C85.9 | 1 | 1 | — | — | — | 2 | |
Non-small-cell lung carcinoma | D002289 | 1 | 1 | — | — | — | 2 | ||
Lymphoma | D008223 | C85.9 | 1 | 2 | — | — | — | 2 | |
Leiomyosarcoma | D007890 | — | 1 | — | — | — | 1 | ||
Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | 1 | — | — | — | 1 | |
Urologic neoplasms | D014571 | C64-C68 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lung neoplasms | D008175 | C34.90 | 2 | — | — | — | — | 2 | |
Leukemia | D007938 | C95 | 2 | — | — | — | — | 2 | |
Squamous cell carcinoma of head and neck | D000077195 | 1 | — | — | — | — | 1 | ||
Squamous cell carcinoma | D002294 | 1 | — | — | — | — | 1 | ||
Prostatic neoplasms | D011471 | C61 | 1 | — | — | — | — | 1 | |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
Melanoma | D008545 | 1 | — | — | — | — | 1 | ||
Rhabdomyosarcoma | D012208 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | MOCETINOSTAT |
INN | mocetinostat |
Description | N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide is a member of benzamides. |
Classification | Small molecule |
Drug class | enzyme inhibitors: histone deacetylase inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | Nc1ccccc1NC(=O)c1ccc(CNc2nccc(-c3cccnc3)n2)cc1 |
Identifiers
PDB | — |
CAS-ID | 726169-73-9 |
RxCUI | — |
ChEMBL ID | CHEMBL272980 |
ChEBI ID | — |
PubChem CID | 9865515 |
DrugBank | DB11830 |
UNII ID | A6GWB8T96J (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
HDAC2
HDAC2
HDAC3
HDAC3
HDAC1
HDAC1
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 900 documents
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Safety
Black-box Warning
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Adverse Events
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7 adverse events reported
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