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Molibresib
Molibresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 3, bromodomain-containing protein 2, and bromodomain-containing protein 4.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8021———3
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277C80.01————1
Drug interactionsD0043471————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Non-hodgkin lymphomaD008228C85.91————1
LymphomaD008223C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMOLIBRESIB
INNmolibresib
Description
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide is a benzodiazepine.
Classification
Small molecule
Drug classextra-terminal motif (BET) family of bromodomain (BRD) proteins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21
Identifiers
PDB—
CAS-ID1260907-17-2
RxCUI—
ChEMBL IDCHEMBL1232461
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID5QIO6SRZ2R (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BRD3
BRD3
BRD2
BRD2
BRD4
BRD4
Organism
Homo sapiens
Gene name
BRD3
Gene synonyms
KIAA0043, RING3L
NCBI Gene ID
8019
Protein name
bromodomain-containing protein 3
Protein synonyms
female sterile homeotic related gene 2, RING3-like protein
Uniprot ID
Q92645
Mouse ortholog
Brd3 (67382)
bromodomain-containing protein 3 (Q9JI25)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 169 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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