Elocon, Atectura breezhaler(mometasone furoate)
Asmanex, Breezhaler, Dulera, Nasonex, Ryaltris, Sinuva (mometasone furoate) is a small molecule pharmaceutical. Mometasone furoate was first approved as Elocon on 1987-04-30. It is used to treat allergic rhinitis perennial, facial dermatoses, foot dermatoses, hand dermatoses, and inflammation amongst others in the USA. It has been approved in Europe to treat asthma.
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Commercial
Trade Name
FDA
EMA
Asmanex, Nasonex, Sinuva (generic drugs available since 2002-03-18, discontinued: Elocon)
CombinationsDulera, Ryaltris
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| asmanex hfa | New Drug Application | 2023-03-24 |
| dulera | New Drug Application | 2021-06-01 |
| elocon | New Drug Application | 2010-08-31 |
| mometasone furoate | ANDA | 2023-01-06 |
| nasonex | New Drug Application | 2023-02-22 |
| ryaltris | New Drug Application | 2022-01-09 |
| sinuva | New Drug Application | 2020-05-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic rhinitis perennial | EFO_1001417 | D012221 | J30.89 |
| facial dermatoses | — | D005148 | — |
| foot dermatoses | — | D005533 | — |
| hand dermatoses | — | D006229 | — |
| inflammation | MP_0001845 | D007249 | — |
| leg dermatoses | — | D007868 | — |
| pruritus | HP_0000989 | D011537 | L29 |
| scalp dermatoses | — | D012536 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MOMETASONE FUROATE / OLOPATADINE HYDROCHLORIDE, RYALTRIS, GLENMARK SPECIALTY | |||
| 2025-01-13 | NP | ||
FORMOTEROL FUMARATE / MOMETASONE FUROATE, DULERA, ORGANON LLC | |||
| 2023-02-12 | PED | ||
MOMETASONE FUROATE, ASMANEX HFA, ORGANON LLC | |||
| 2023-02-12 | PED | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Mometasone Furoate, Sinuva, Intersect Ent Inc | |||
| 10232152 | 2034-11-24 | DP | U-2272 |
| 10406332 | 2034-03-13 | DP | |
| 8763222 | 2032-02-08 | DP | |
| 10357640 | 2031-10-03 | U-2272 | |
| 8025635 | 2027-06-12 | DP | U-2272 |
| 7544192 | 2026-11-29 | U-2272 | |
| 9585681 | 2026-04-04 | U-2272 | |
| 7662141 | 2024-03-12 | U-2272 | |
| 7713255 | 2024-03-12 | U-2272 | |
| 7951130 | 2024-03-12 | U-2272 | |
| 7951131 | 2024-03-12 | U-2272 | |
| 7951133 | 2024-03-12 | U-2272 | |
| 8109918 | 2024-03-12 | U-2272 | |
| Mometasone Furoate / Olopatadine Hydrochloride, Ryaltris, Glenmark Specialty | |||
| 9078923 | 2034-09-04 | DP | U-3297 |
| 9370483 | 2034-09-04 | DP | |
| 9750754 | 2034-09-04 | DP | U-3297 |
| 9937189 | 2034-09-04 | DP | |
| 10016443 | 2034-09-04 | U-3297 | |
| 10376526 | 2034-09-04 | DP | |
| 10517880 | 2034-09-04 | DP | U-3297 |
| 10548907 | 2034-09-04 | U-3297 | |
| 10561672 | 2034-09-04 | DP | |
| 10646500 | 2034-09-04 | U-3297 | |
| 10758550 | 2034-09-04 | U-3296 | |
| 10765686 | 2034-09-04 | U-3295 | |
| 11400101 | 2034-09-04 | U-3297 | |
ATC Codes
No data
HCPCS
Code | Description |
|---|---|
| J7402 | Mometasone furoate sinus implant, (sinuva), 10 micrograms |
Clinical
Clinical Trials
194 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 13 | 13 | 14 | 6 | 47 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | 2 | 4 | 13 | 5 | 1 | 24 |
| Allergic rhinitis | D065631 | J30.9 | 2 | — | 9 | 5 | 2 | 18 | |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | — | 1 | 12 | 2 | 1 | 16 |
| Nasal polyps | D009298 | HP_0100582 | J33 | — | 3 | 8 | 4 | — | 13 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | 1 | — | 3 | — | 6 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 3 | — | 1 | — | 5 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 1 | 3 | 1 | 5 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | — | 2 | 1 | 1 | 4 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | 3 | — | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | 3 | — | — | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 3 | — | — | 3 |
| Conjunctivitis | D003231 | H10 | — | — | 2 | — | — | 2 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 2 | — | — | 2 |
| Covid-19 | D000086382 | U07.1 | — | — | 1 | — | — | 1 | |
| Anosmia | D000086582 | — | — | 1 | — | — | 1 | ||
| Pruritus | D011537 | HP_0000989 | L29 | — | — | 1 | — | — | 1 |
| Sneezing | D012912 | R06.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 2 | — | — | — | 2 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | — | — | — | 1 |
| Inflammation | D007249 | — | 1 | — | — | — | 1 | ||
| Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | 1 | 4 | ||
| Spinal cord injuries | D013119 | EFO_1001919 | 1 | — | — | — | — | 1 | |
| Alopecia areata | D000506 | EFO_0004192 | L63 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | R07.0 | — | — | — | — | 1 | 1 | |
| Stents | D015607 | — | — | — | — | 1 | 1 | ||
| Frontal sinusitis | D015522 | J32.1 | — | — | — | — | 1 | 1 | |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | — | 1 | 1 |
| Vulvar lichen sclerosus | D007724 | N90.4 | — | — | — | — | 1 | 1 | |
| Vasomotor rhinitis | D012223 | EFO_0007533 | J30.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MOMETASONE FUROATE |
| INN | — |
| Description | Mometasone furoate is a 2-furoate ester, a steroid ester, an 11beta-hydroxy steroid, a 20-oxo steroid, an organochlorine compound and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug and an anti-allergic agent. It is functionally related to a mometasone. |
| Classification | Small molecule |
| Drug class | Corticosteroid; Glucocorticoid |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl |
Identifiers
| PDB | — |
| CAS-ID | 83919-23-7 |
| RxCUI | 30145 |
| ChEMBL ID | CHEMBL1161 |
| ChEBI ID | 47564 |
| PubChem CID | 441336 |
| DrugBank | DB00764 |
| UNII ID | — |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
Nasonex - Organon
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Nasonex - Merck Sharp & Dohme
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Dulera - Organon
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Dulera - Merck Sharp & Dohme
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Asmanex - Organon
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Tabular view
Trends
PubMed Central
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Additional graphs summarizing 2,286 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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761 adverse events reported
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