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Nafamostat
Nafamostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine protease 1, complement C1r subcomponent, and tryptase alpha/beta-1. In addition, it is known to target transient receptor potential cation channel subfamily M member 7, acid-sensing ion channel 2, acid-sensing ion channel 1, acid-sensing ion channel 3, transmembrane protease serine 2, and urokinase-type plasminogen activator.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute kidney injuryD058186HP_0001919N17——12—3
Liver transplantationD016031EFO_0010682———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1154——7
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Critical illnessD016638—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD0105992————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNAFAMOSTAT
INNnafamostat
Description
Nafamostat is a member of benzoic acids and a member of guanidines.
Classification
Small molecule
Drug classenzyme inhibitors: proteolytic enzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1
Identifiers
PDB7VM7
CAS-ID81525-10-2
RxCUI—
ChEMBL IDCHEMBL273264
ChEBI ID—
PubChem CID4413
DrugBankDB12598
UNII IDY25LQ0H97D (ChemIDplus, GSRS)
Target
Agency Approved
PRSS1
PRSS1
C1R
C1R
TPSAB1
TPSAB1
Organism
Homo sapiens
Gene name
PRSS1
Gene synonyms
TRP1, TRY1, TRYP1
NCBI Gene ID
5644
Protein name
serine protease 1
Protein synonyms
Anionic trypsin I, Anionic trypsin-I, Beta-trypsin, Cationic trypsinogen, digestive zymogen, nonfunctional trypsin 1, Pretrypsinogen I, protease, serine 1, TCR V beta 4.1, Trypsin I, Trypsin-1, trypsinogen 1, trypsinogen A
Uniprot ID
Q9HAN7
Mouse ortholog
—
—
Alternate
TRPM7
TRPM7
ASIC2
ASIC2
ASIC1
ASIC1
ASIC3
ASIC3
TMPRSS2
TMPRSS2
PLAU
PLAU
Organism
Homo sapiens
Gene name
TRPM7
Gene synonyms
CHAK1, LTRPC7
NCBI Gene ID
54822
Protein name
transient receptor potential cation channel subfamily M member 7
Protein synonyms
Channel-kinase 1, Long transient receptor potential channel 7, LTRPC ion channel family member 7, LTrpC-7, LTrpC7, transient receptor potential-phospholipase C-interacting kinase
Uniprot ID
Q96QT4
Mouse ortholog
Trpm7 (58800)
transient receptor potential cation channel subfamily M member 7 (Q923J1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,590 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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100 adverse events reported
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