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Lxh254
Lxh254 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target platelet-derived growth factor receptor beta, RAF proto-oncogene serine/threonine-protein kinase, epithelial discoidin domain-containing receptor 1, serine/threonine-protein kinase B-raf, and discoidin domain-containing receptor 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD00854521———3
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD0022892————2
Ovarian neoplasmsD010051EFO_0003893C561————1
NeoplasmsD009369C801————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLXH254
INNnaporafenib
Description
Lxh254 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target platelet-derived growth factor receptor beta, RAF proto-oncogene serine/threonine-protein kinase, epithelial discoidin domain-containing receptor 1, serine/threonine-protein kinase B-raf, and discoidin domain-containing receptor 2.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1
Identifiers
PDB—
CAS-ID1800398-38-2
RxCUI—
ChEMBL IDCHEMBL4583691
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID15JL80DG6H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PDGFRB
PDGFRB
RAF1
RAF1
DDR1
DDR1
BRAF
BRAF
DDR2
DDR2
Organism
Homo sapiens
Gene name
PDGFRB
Gene synonyms
PDGFR, PDGFR1
NCBI Gene ID
5159
Protein name
platelet-derived growth factor receptor beta
Protein synonyms
Activated tyrosine kinase PDGFRB, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, NDEL1-PDGFRB, PDGF-R-beta, PDGFR-1, PDGFR-beta, Platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide
Uniprot ID
Q8N5L4
Mouse ortholog
Pdgfrb (18596)
platelet-derived growth factor receptor beta (P05622)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 85 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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27 adverse events reported
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