Navtemadlin
Navtemadlin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | C92.0 | 5 | 2 | — | — | — | 5 | |
| Merkel cell carcinoma | D015266 | EFO_1001471 | C4A | 1 | 1 | — | — | — | 1 |
| Polycythemia vera | D011087 | D45 | — | 1 | — | — | — | 1 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | 1 | — | — | — | 1 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | 1 | — | — | — | 1 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | 1 | — | — | — | 1 | |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | 1 | 1 | — | — | — | 1 | |
| Small cell lung carcinoma | D055752 | — | 1 | — | — | — | 1 | ||
| Non-small-cell lung carcinoma | D002289 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 3 | — | — | — | — | 3 | |
| Cancer pain | D000072716 | G89.3 | 3 | — | — | — | — | 3 | |
| Multiple myeloma | D009101 | C90.0 | 2 | — | — | — | — | 2 | |
| Glioblastoma | D005909 | EFO_0000515 | 2 | — | — | — | — | 2 | |
| Plasmacytoma | D010954 | C90.3 | 1 | — | — | — | — | 1 | |
| Melanoma | D008545 | 1 | — | — | — | — | 1 | ||
| Myelodysplastic syndromes | D009190 | D46 | 1 | — | — | — | — | 1 | |
| Sarcoma | D012509 | 1 | — | — | — | — | 1 | ||
| Gliosarcoma | D018316 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NAVTEMADLIN |
| INN | navtemadlin |
| Description | Navtemadlin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Small molecule |
| Drug class | ubiquitin ligase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)[C@@H](CS(=O)(=O)C(C)C)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1352066-68-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3125702 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 7R7G6EH5UL (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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