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Nelivaptan
Nelivaptan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vasopressin V2 receptor, vasopressin V1a receptor, vasopressin V1b receptor, and oxytocin receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A—2———2
Major depressive disorderD003865EFO_0003761F22—1———1
Anxiety disordersD001008EFO_0006788F41.1—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNELIVAPTAN
INNnelivaptan
Description
Nelivaptan (INN) (developmental codename SSR-149,415) is a selective, orally active, non-peptide vasopressin receptor antagonist selective for the V1B subtype. The drug had entered clinical trials for treatment of anxiety and depression. In July 2008, Sanofi-Aventis announced that further development of this drug had been halted.
Classification
Small molecule
Drug classaptamers, classical and mirror; vasopressin receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccccc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1
Identifiers
PDB—
CAS-ID439687-69-1
RxCUI—
ChEMBL IDCHEMBL582857
ChEBI ID—
PubChem CID9895468
DrugBankDB12643
UNII ID3TY57MQ4OA (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AVPR2
AVPR2
AVPR1A
AVPR1A
AVPR1B
AVPR1B
OXTR
OXTR
Organism
Homo sapiens
Gene name
AVPR2
Gene synonyms
ADHR, DIR, DIR3, V2R
NCBI Gene ID
554
Protein name
vasopressin V2 receptor
Protein synonyms
Antidiuretic hormone receptor, AVPR V2, Renal-type arginine vasopressin receptor
Uniprot ID
Q9UCV9
Mouse ortholog
Avpr2 (12000)
vasopressin V2 receptor (O88721)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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