Neomycin
Casporyn, Coly-mycin, Cor-oticin, Cordran, Cortisporin, Lanabiotic, Lumi-sporyn, Maxitrol, Mycifradin, Mycitracin, Mytrex A, Neo-cort-dome, Neo-cortef, Neo-delta-cortef, Neo-fradin, Neo-hydeltrasol, Neo-medrol, Neo-polycin, Neobiotic, Neodecadron, Neosporin, Poly-pred, Statrol (neomycin) is a small molecule pharmaceutical. Neomycin was first approved as Neo-cort-dome on 1982-01-01. It is used to treat bacterial infections, bacterial skin diseases, escherichia coli infections, and hepatic encephalopathy in the USA. It is known to target extracellular calcium-sensing receptor.
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Commercial
Trade Name
FDA
EMA
Combinations
Casporyn, Coly-mycin, Lumi-sporyn, Maxitrol (generic drugs available since 1982-01-01, discontinued: Cor-oticin, Cordran, Cortisporin, Dexacidin, Dexasporin, Lanabiotic, Mycitracin, Mytrex a, Neo-cort-dome, Neo-cortef, Neo-delta-cortef, Neo-hydeltrasol, Neo-medrol, Neo-polycin, Neodecadron, Neosporin, Oticair, Otobione, Otocort, Pediotic, Poly-pred, Statrol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetic acid
+
glacial
+
Hydrocortisone
+
Neomycin sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NEO-CORT-DOME | Bayer | N-050238 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Bacitracin zinc
+
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Bacitracin zinc
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LUMI-SPORYN | Casper Pharma | N-050417 RX | 1982-01-01 | 1 products, RLD |
Colistin sulfate
+
Hydrocortisone acetate
+
Neomycin sulfate
+
Thonzonium bromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLY-MYCIN S | Endo | N-050356 RX | 1982-01-01 | 1 products, RLD, RS |
Dexamethasone
+
Neomycin sulfate
+
Polymyxin b sulfate
Dexamethasone sodium phosphate
+
Neomycin sulfate
Flurandrenolide
+
Neomycin sulfate
Hydrocortisone
+
Neomycin sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NEO-CORT-DOME | Bayer | N-050237 DISCN | 1984-06-05 | 2 products |
Hide discontinued
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CASPORYN HC | Casper Pharma | N-060613 RX | 1982-01-01 | 1 products, RLD, RS |
Show 2 discontinued
Hydrocortisone acetate
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CORTISPORIN | Monarch Pharmaceuticals | N-050218 DISCN | 1985-08-09 | 1 products, RLD |
Hide discontinued
Neomycin sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MYCIFRADIN | Pharmacia & Upjohn | N-050285 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Neomycin sulfate
+
Polymyxin b sulfate
Neomycin sulfate
+
Polymyxin b sulfate
+
Prednisolone acetate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| POLY-PRED | Allergan | N-050081 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Neomycin sulfate
+
Prednisolone sodium phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NEO-HYDELTRASOL | Merck KGaA | N-050378 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| care science essential first aid | OTC monograph not final | 2023-06-19 |
| casporyn hc | New Drug Application | 2019-09-26 |
| coly-mycin | New Drug Application | 2018-12-03 |
| cordran | New Drug Application | 2023-01-13 |
| cortisporin tc | New Drug Application | 2019-01-15 |
| maxitrol | New Drug Application | 2022-11-10 |
| neo-polycin | ANDA | 2012-09-26 |
| neo-synalar | ANDA | 2018-12-06 |
| neosporin plus pain relief | OTC monograph final | 2023-02-10 |
| statrol | 2006-05-12 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB08: Neomycin
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA01: Neomycin
— A07AA51: Neomycin, combinations
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA09: Neomycin
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AX: Other antibiotics for topical use in atc
— D06AX04: Neomycin
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01G: Aminoglycoside antibacterials
— J01GB: Other aminoglycosides in atc
— J01GB05: Neomycin
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AB: Antibiotic throat preparations
— R02AB01: Neomycin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA03: Neomycin
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA07: Neomycin
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA01: Neomycin
HCPCS
No data
Clinical
Clinical Trials
130 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 15 | 25 | 16 | 7 | 25 | 88 |
| Healthy volunteers/patients | — | 1 | — | — | 2 | — | 3 | ||
| Lipodystrophy | D008060 | E88.1 | 1 | — | — | 1 | — | 2 | |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | 1 | — | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | — | 1 |
| Hiv-associated lipodystrophy syndrome | D039682 | EFO_1001348 | — | — | — | 1 | — | 1 | |
| Hepatitis c | D006526 | B19.2 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine cervical neoplasms | D002583 | 2 | — | 1 | — | — | 3 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 1 | — | — | 2 |
| Aids-associated nephropathy | D016263 | EFO_0007313 | — | — | 1 | — | — | 1 | |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 4 | 1 | — | — | — | 4 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 2 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | 3 | — | — | — | 3 | ||
| Kaposi sarcoma | D012514 | C46 | 1 | 2 | — | — | — | 3 | |
| Renal cell carcinoma | D002292 | 1 | 1 | — | — | — | 2 | ||
| Mycobacterium avium-intracellulare infection | D015270 | EFO_0007386 | — | 1 | — | — | 1 | 2 | |
| Multiple myeloma | D009101 | C90.0 | 2 | 1 | — | — | — | 2 | |
| Sarcoma | D012509 | 1 | 2 | — | — | — | 2 | ||
| Lung neoplasms | D008175 | C34.90 | 2 | 2 | — | — | — | 2 | |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | 1 | — | — | — | 1 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | 2 | — | — | — | — | 2 | |
| Leukemia | D007938 | C95 | 1 | — | — | — | — | 1 | |
| Plasma cell neoplasms | D054219 | 1 | — | — | — | — | 1 | ||
| Hiv seronegativity | D018023 | 1 | — | — | — | — | 1 | ||
| Glioma | D005910 | EFO_0000520 | 1 | — | — | — | — | 1 | |
| Central nervous system neoplasms | D016543 | 1 | — | — | — | — | 1 | ||
| Glioblastoma | D005909 | EFO_0000515 | 1 | — | — | — | — | 1 | |
| Cardiopulmonary bypass | D002315 | 1 | — | — | — | — | 1 | ||
| Vulvar neoplasms | D014846 | C51 | 1 | — | — | — | — | 1 | |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NEOMYCIN |
| INN | neomycin |
| Description | Framycetin is a tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. It has a role as an antibacterial drug, an allergen and an Escherichia coli metabolite. It is a conjugate base of a framycetin(6+). |
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1404-04-2 |
| RxCUI | 7299 |
| ChEMBL ID | CHEMBL3989751 |
| ChEBI ID | — |
| PubChem CID | 8378 |
| DrugBank | DB00994 |
| UNII ID | I16QD7X297 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CASR
CASR
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,503 adverse events reported
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