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Rhopressa, Rhokiinsa(netarsudil)
Rhokiinsa, Rhopressa, Rocklatan, Roclanda (netarsudil) is a small molecule pharmaceutical. Netarsudil was first approved as Rhopressa on 2017-12-18. It is used to treat ocular hypertension and open-angle glaucoma in the USA. It has been approved in Europe to treat ocular hypertension and open-angle glaucoma. It is known to target rho-associated protein kinase 1 and rho-associated protein kinase 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Rhopressa
Combinations
Rocklatan
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Latanoprost
+
Netarsudil dimesylate
Tradename
Company
Number
Date
Products
ROCKLATANAlcon ResearchN-208259 RX2019-03-12
1 products, RLD, RS
Netarsudil mesylate
Tradename
Company
Number
Date
Products
RHOPRESSAAlcon ResearchN-208254 RX2017-12-18
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
rhopressaNew Drug Application2020-10-29
rocklatanNew Drug Application2021-12-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ocular hypertensionEFO_1001069D009798H40.0
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Latanoprost / Netarsudil Dimesylate, Rocklatan, Alcon Labs Inc
94150432034-03-14DP
99313362034-03-14DS, DPU-1524
99934702034-03-14DS, DPU-1524
105889012034-03-14DS, DPU-1524
111855382034-03-14DP
111978532034-03-14DP
83948262030-11-10DS, DPU-1524
101740172030-01-27DS, DPU-1524
106548442030-01-27DS, DPU-1524
110280812030-01-27U-1524
116187482030-01-27U-1524
84503442026-07-11DS, DPU-1524
90965692026-07-11DS, DPU-1524
105329932026-07-11U-1524
108828402026-07-11U-1524
110214562026-07-11U-1524
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EE: Prostaglandin analogues, antiglaucoma drugs and miotics
— S01EE51: Latanoprost and netarsudil
— S01EX: Other antiglaucoma preparations in atc
— S01EX05: Netarsudil
HCPCS
No data
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Open-angle glaucomaD005902EFO_0004190H40.11771117
Ocular hypertensionD009798EFO_1001069H40.0—581216
GlaucomaD005901EFO_0000516H40——11—2
Low tension glaucomaD057066EFO_1001022H40.12———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fuchs' endothelial dystrophyD005642EFO_0003946H18.51223——5
Proliferative vitreoretinopathyD018630EFO_1001129—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Corneal edemaD015715EFO_1000879H18.20—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
CataractD002386EFO_0001059H26.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNETARSUDIL
INNnetarsudil
Description
Netarsudil, sold under the brand name Rhopressa among others, is a medication for the treatment of glaucoma. In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the lowering of elevated intraocular pressure in people with open-angle glaucoma or ocular hypertension. The European Medicines Agency approved it in 2019 for the same uses under the brand name Rhokiinsa.
Classification
Small molecule
Drug classvasodilators (undefined group): Rho protein kinase (ROCK) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1
Identifiers
PDB—
CAS-ID1254032-66-0
RxCUI—
ChEMBL IDCHEMBL4594250
ChEBI ID—
PubChem CID66599893
DrugBankDB13931
UNII IDW6I5QDT7QI (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ROCK1
ROCK1
ROCK2
ROCK2
Organism
Homo sapiens
Gene name
ROCK1
Gene synonyms
NCBI Gene ID
6093
Protein name
rho-associated protein kinase 1
Protein synonyms
p160 ROCK-1, p160ROCK, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I
Uniprot ID
Q59GZ4
Mouse ortholog
Rock1 (19877)
rho-associated protein kinase 1 (Q8C7H0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 346 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,672 adverse events reported
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