Nicorandil
Nicorandil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target ATP-sensitive inward rectifier potassium channel 11 and ATP-sensitive inward rectifier potassium channel 8.
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | I25.1 | — | 1 | — | 4 | 1 | 6 | |
| Coronary disease | D003327 | — | — | — | 3 | — | 3 | ||
| Stable angina | D060050 | I20.8 | — | — | — | 3 | — | 3 | |
| Percutaneous coronary intervention | D062645 | — | — | — | 3 | — | 3 | ||
| St elevation myocardial infarction | D000072657 | — | — | — | 2 | — | 2 | ||
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | 1 | — | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 2 | — | 2 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | 1 | — | 1 | |
| Pilot projects | D010865 | — | — | — | 1 | — | 1 | ||
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | — | 1 | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 2 | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | 2 | 2 | |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Microvascular angina | D017566 | — | — | — | — | 1 | 1 | ||
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NICORANDIL |
| INN | nicorandil |
| Description | Nicorandil is a pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. It has a role as a vasodilator agent and a potassium channel opener. It is a pyridinecarboxamide and a nitrate ester. It is functionally related to a nicotinamide. |
| Classification | Small molecule |
| Drug class | vasodilators (undefined group) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(NCCO[N+](=O)[O-])c1cccnc1 |
Identifiers
| PDB | — |
| CAS-ID | 65141-46-0 |
| RxCUI | 31748 |
| ChEMBL ID | CHEMBL284906 |
| ChEBI ID | 31905 |
| PubChem CID | 47528 |
| DrugBank | DB09220 |
| UNII ID | 260456HAM0 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
KCNJ11
KCNJ11
KCNJ8
KCNJ8
Organism
Homo sapiens
Gene name
KCNJ11
Gene synonyms
NCBI Gene ID
Protein name
ATP-sensitive inward rectifier potassium channel 11
Protein synonyms
beta-cell inward rectifier subunit, IKATP, Inward rectifier K(+) channel Kir6.2, inwardly rectifing potassium channel subfamily J member 11, inwardly rectifying potassium channel KIR6.2, inwardly-rectifying potassium channel subfamily J member 11, potassium channel inwardly rectifing subfamily J member 11, Potassium channel, inwardly rectifying subfamily J member 11, potassium voltage-gated channel subfamily J member 11
Uniprot ID
Mouse ortholog
Kcnj11 (16514)
ATP-sensitive inward rectifier potassium channel 11 (Q9QX21)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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752 adverse events reported
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