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Nimodipine
Nymalize (nimodipine) is a small molecule pharmaceutical. Nimodipine was first approved as Nimotop on 1988-12-28. It is used to treat subarachnoid hemorrhage in the USA. The pharmaceutical is active against mineralocorticoid receptor. In addition, it is known to target cystic fibrosis transmembrane conductance regulator, voltage-dependent L-type calcium channel subunit alpha-1F, voltage-dependent L-type calcium channel subunit alpha-1D, voltage-dependent L-type calcium channel subunit alpha-1S, and voltage-dependent L-type calcium channel subunit alpha-1C.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Nymalize (generic drugs available since 2007-05-02, discontinued: Nimotop)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nimodipine
Tradename
Company
Number
Date
Products
NYMALIZEAzurityN-203340 RX2020-04-08
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
nymalizeNew Drug Application2021-04-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
subarachnoid hemorrhageEFO_0000713D013345I60
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Nimodipine, Nymalize, Azurity
103427872038-04-16DPU-2804
105760702038-04-16DPU-2804
112073062038-04-16U-2804
114132772038-04-16DPU-2804
115175632038-04-16DP
85179972024-05-14DP
70705812023-06-23DP
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA06: Nimodipine
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61155——10
AdenocarcinomaD000230—21——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNIMODIPINE
INNnimodipine
Description
Nimodipine is a dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and a cardiovascular drug. It is a dihydropyridine, a C-nitro compound, a diester, a member of dicarboxylic acids and O-substituted derivatives, a 2-methoxyethyl ester and an isopropyl ester.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1
Identifiers
PDB5KMF
CAS-ID66085-59-4
RxCUI7426
ChEMBL IDCHEMBL1428
ChEBI ID7575
PubChem CID4497
DrugBankDB00393
UNII ID57WA9QZ5WH (ChemIDplus, GSRS)
Target
Agency Approved
NR3C2
NR3C2
Organism
Homo sapiens
Gene name
NR3C2
Gene synonyms
MCR, MLR
NCBI Gene ID
4306
Protein name
mineralocorticoid receptor
Protein synonyms
aldosterone receptor, mineralocorticoid receptor 1, mineralocorticoid receptor 2, mineralocorticoid receptor delta, Nuclear receptor subfamily 3 group C member 2
Uniprot ID
Q96KQ9
Mouse ortholog
Nr3c2 (110784)
mineralocorticoid receptor (Q8VII8)
Alternate
CFTR
CFTR
CACNA1F
CACNA1F
CACNA1D
CACNA1D
CACNA1S
CACNA1S
CACNA1C
CACNA1C
Organism
Homo sapiens
Gene name
CFTR
Gene synonyms
ABCC7
NCBI Gene ID
1080
Protein name
cystic fibrosis transmembrane conductance regulator
Protein synonyms
ATP-binding cassette sub-family C member 7, cAMP-dependent chloride channel, Channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulating, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Uniprot ID
Q2I102
Mouse ortholog
Cftr (12638)
cystic fibrosis transmembrane conductance regulator (Q9JKQ6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 7,744 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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81 adverse events reported
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