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Nitrendipine
Nitrendipine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against voltage-dependent L-type calcium channel subunit alpha-1D. In addition, it is known to target intermediate conductance calcium-activated potassium channel protein 4, voltage-dependent L-type calcium channel subunit alpha-1C, voltage-dependent L-type calcium channel subunit alpha-1S, and voltage-dependent L-type calcium channel subunit alpha-1F.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA08: Nitrendipine
— C09: Agents acting on the renin-angiotensin system
— C09B: Ace inhibitors, combinations
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB06: Enalapril and nitrendipine
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10———325
Chronic renal insufficiencyD051436N18———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNITRENDIPINE
INNnitrendipine
Description
Nitrendipine is a dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension. It has a role as a calcium channel blocker, an antihypertensive agent, a vasodilator agent and a geroprotector. It is a C-nitro compound, a dihydropyridine, an ethyl ester, a diester, a member of dicarboxylic acids and O-substituted derivatives and a methyl ester.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1
Identifiers
PDB—
CAS-ID39562-70-4
RxCUI7441
ChEMBL IDCHEMBL475534
ChEBI ID7582
PubChem CID4507
DrugBankDB01054
UNII ID9B627AW319 (ChemIDplus, GSRS)
Target
Agency Approved
CACNA1D
CACNA1D
Organism
Homo sapiens
Gene name
CACNA1D
Gene synonyms
CACH3, CACN4, CACNL1A2, CCHL1A2
NCBI Gene ID
776
Protein name
voltage-dependent L-type calcium channel subunit alpha-1D
Protein synonyms
calcium channel, L type, alpha-1 polypeptide, Calcium channel, L type, alpha-1 polypeptide, isoform 2, calcium channel, neuroendocrine/brain-type, alpha 1 subunit, calcium channel, voltage-dependent, L type, alpha 1D subunit, voltage-gated calcium channel alpha 1 subunit, voltage-gated calcium channel alpha subunit Cav1.3, Voltage-gated calcium channel subunit alpha Cav1.3
Uniprot ID
Q01668
Mouse ortholog
Cacna1d (12289)
voltage-dependent L-type calcium channel subunit alpha-1D (Q99246)
Alternate
KCNN4
KCNN4
CACNA1C
CACNA1C
CACNA1S
CACNA1S
CACNA1F
CACNA1F
Organism
Homo sapiens
Gene name
KCNN4
Gene synonyms
IK1, IKCA1, KCA4, SK4
NCBI Gene ID
3783
Protein name
intermediate conductance calcium-activated potassium channel protein 4
Protein synonyms
IK1, IKCa1, intermediate-conductance Ca2+-activated K+ channel, KCa3.1, KCa3.1, KCa4, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel, Putative Gardos channel, SKCa 4, SKCa4, small conductance calcium-activated potassium channel 4
Uniprot ID
Q53XR4
Mouse ortholog
Kcnn4 (16534)
intermediate conductance calcium-activated potassium channel protein 4 (Q9CY39)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,002 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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348 adverse events reported
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