Skip to content
Nitrofurantoin
Furadantin, Ivadantin, Macrobid, Macrodantin (nitrofurantoin) is a small molecule pharmaceutical. Nitrofurantoin was first approved as Furadantin on 1982-01-01. It is used to treat bacterial infections, escherichia coli infections, klebsiella infections, staphylococcal infections, and urinary tract infections in the USA.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
Furadantin, Macrodantin (generic drugs available since 1993-01-28, discontinued: Furalan, Ivadantin)
Combinations
Macrobid (generic drugs available since 1993-01-28)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nitrofurantoin
Tradename
Company
Number
Date
Products
FURADANTINCasper PharmaN-009175 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Nitrofurantoin
+
Nitrofurantoin
+
macrocrystalline
Tradename
Company
Number
Date
Products
MACROBIDAlmatica PharmaN-020064 RX1991-12-24
1 products, RLD, RS
Nitrofurantoin sodium
Tradename
Company
Number
Date
Products
IVADANTINProcter And GambleN-012402 DISCN1982-01-01
1 products
Hide discontinued
Nitrofurantoin
+
macrocrystalline
Tradename
Company
Number
Date
Products
MACRODANTINAlmatica PharmaN-016620 RX1982-01-01
3 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
furadantinNew Drug Application2021-01-04
macrobidNew Drug Application2020-12-31
macrodantinNew Drug Application2020-06-01
nitrofurantoin macrocrystalsNew Drug Application2023-05-16
nitrofurantoin monohydrate/ macrocrystallineNew Drug Application2023-06-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infectionsD001424A49
escherichia coli infectionsEFO_1001318D004927B96.20
klebsiella infectionsEFO_1001353D007710
staphylococcal infectionsD013203A49.01
urinary tract infectionsEFO_0003103D014552N39.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01X: Other antibacterials in atc
J01XE: Nitrofuran derivatives, antibacterials for systemic use
J01XE01: Nitrofurantoin
J01XE51: Nitrofurantoin, combinations
HCPCS
No data
Clinical
Clinical Trials
40 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary tract infectionsD014552EFO_0003103N39.012412423
CystitisD003556EFO_1000025N30123
NephrolithiasisD053040N20.0112
Pelvic organ prolapseD056887EFO_0004710112
PulpitisD011671EFO_1001139K04.022
Urinary bladder neoplasmsD001749C6711
Kidney calculiD007669EFO_0004253N20.011
Stress urinary incontinenceD014550HP_001099211
Postoperative painD010149G89.1811
Prostatic hyperplasiaD011470EFO_0000284N4011
Show 2 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic renal insufficiencyD051436N1811
Vesico-ureteral refluxD014718EFO_0007536N13.711
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients314
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805A41.911
Urinary incontinenceD014549HP_0000020R3211
Asymptomatic diseasesD05807011
HematuriaD006417HP_0000790R3111
Pregnancy complicationsD01124811
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameNITROFURANTOIN
INNnitrofurantoin
Description
Nitrofurantoin is an imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA. It has a role as a hepatotoxic agent, an antiinfective agent and an antibacterial drug. It is an organonitrogen heterocyclic antibiotic, an organooxygen heterocyclic antibiotic, a nitrofuran antibiotic and an imidazolidine-2,4-dione. It is functionally related to a semicarbazide.
Classification
Small molecule
Drug classantiepileptics (hydantoin derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1CN(/N=C/c2ccc([N+](=O)[O-])o2)C(=O)N1
Identifiers
PDB
CAS-ID67-20-9
RxCUI7454
ChEMBL IDCHEMBL572
ChEBI ID71415
PubChem CID6604200
DrugBankDB00698
UNII ID927AH8112L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Nitrofurantoin - RVL Pharmaceuticals
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 11,275 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
606 adverse events reported
View more details