Nitroprusside
Nipride (nitroprusside) is a small molecule pharmaceutical. Nitroprusside was first approved as Nitropress on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Nipride (generic drugs available since 2016-12-08, discontinued: Nitropress)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium nitroprusside
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NIPRIDE RTU IN SODIUM CHLORIDE 0.9% | Exela Pharma Sciences | N-209387 RX | 2017-03-08 | 2 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nipride rtu | New Drug Application | 2018-07-20 |
| sodium nitroprusside | ANDA | 2023-02-16 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | 2 | 2 | — | 6 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | 1 | — | 1 | — | 2 |
| Coronary artery disease | D003324 | I25.1 | 1 | — | — | 1 | — | 2 | |
| Ischemic stroke | D000083242 | — | — | — | 1 | — | 1 | ||
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 1 | — | 1 | |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral hemorrhage | D002543 | 1 | — | 1 | — | 2 | 4 | ||
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | — | — | 1 | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | 1 | — | — | 1 | 2 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | T88.7 | 1 | — | — | — | — | 1 | |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 1 | 1 |
| Intratracheal intubation | D007442 | — | — | — | — | 1 | 1 | ||
| Healthy volunteers/patients | — | — | — | — | — | 1 | 1 | ||
| Cardiopulmonary bypass | D002315 | — | — | — | — | 1 | 1 | ||
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NITROPRUSSIDE |
| INN | — |
| Description | Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. This may be done if the blood pressure is very high and resulting in symptoms, in certain types of heart failure, and during surgery to decrease bleeding. It is used by continuous injection into a vein. Onset is typically immediate and effects last for up to ten minutes.
|
| Classification | Small molecule |
| Drug class | atropine derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O.O.[C]#N.[C]#N.[C]#N.[C]#N.[C]#N.[Fe-].[N-]=O.[Na+].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 13755-38-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2097081 |
| ChEBI ID | 7596 |
| PubChem CID | 11953895 |
| DrugBank | DB00325 |
| UNII ID | — |
Target
Agency Approved
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Alternate
No data
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Nipride rtu, Sodium nitroprusside
Adverse Events
Top Adverse Reactions
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2,486 adverse events reported
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