Nonacog alfa
BeneFIX (nonacog alfa) is a protein pharmaceutical. Nonacog alfa was first approved as Benefix on 1997-08-27. It is used to treat factor VII deficiency, hemophilia a, hemophilia b, and hypoprothrombinemias in the USA. It has been approved in Europe to treat hemophilia b.
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Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia b | D002836 | D67 | 6 | 6 | 15 | 7 | 5 | 35 | |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | 1 | 1 | 3 | 6 |
| Cardiopulmonary bypass | D002315 | — | — | — | 1 | — | 1 | ||
| Mortality | D009026 | EFO_0004352 | — | — | — | 1 | — | 1 | |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 1 | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | 1 | — | 1 |
| Platelet transfusion | D017713 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | 1 | — | — | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | 1 | — | — | 1 |
| Hemorrhagic disorders | D006474 | D69.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NONACOG ALFA |
| INN | nonacog alfa |
| Description | BeneFIX (nonacog alfa) is a protein pharmaceutical. Nonacog alfa was first approved as Benefix on 1997-08-27. It is used to treat factor vii deficiency, hemophilia a, hemophilia b, and hypoprothrombinemias in the USA. It has been approved in Europe to treat hemophilia b. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109205 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 382L14738L (ChemIDplus, GSRS) |
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Benefix - Pfizer
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Additional graphs summarizing 240 documents
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Safety
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Adverse Events
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56,533 adverse events reported
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