Nortriptyline
Pamelor (nortriptyline) is a small molecule pharmaceutical. Nortriptyline was first approved as Aventyl hydrochloride on 1982-01-01. It is used to treat anxiety disorders, attention deficit disorder with hyperactivity, depressive disorder, enuresis, and pain amongst others in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target ATP-sensitive inward rectifier potassium channel 10, G protein-activated inward rectifier potassium channel 2, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Trade Name
FDA
EMA
Pamelor (generic drugs available since 1992-03-30, discontinued: Aventyl)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nortriptyline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PAMELOR | SPECGX | N-018013 RX | 1982-01-01 | 4 products, RLD |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nortriptyline hydrochloride | ANDA | 2023-05-31 |
| pamelor | New Drug Application | 2020-02-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anxiety disorders | EFO_0006788 | D001008 | F41.1 |
| attention deficit disorder with hyperactivity | EFO_0003888 | D001289 | F90 |
| depressive disorder | EFO_1002014 | D003866 | F32.A |
| enuresis | — | D004775 | R32 |
| pain | EFO_0003843 | D010146 | R52 |
| psychotic affective disorders | — | D000341 | F39 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
523 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 149 | 1 | — | 4 | 1 | 155 | ||
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 5 | 12 | 5 | 1 | — | 19 |
| Cataract | D002386 | EFO_0001059 | H26.9 | 1 | — | 1 | 9 | 2 | 13 |
| Infections | D007239 | EFO_0000544 | 5 | 1 | 3 | 1 | 1 | 11 | |
| Endophthalmitis | D009877 | 2 | 5 | 3 | 4 | — | 11 | ||
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 2 | 5 | 2 | 1 | 10 |
| Bacterial infections | D001424 | A49 | 3 | — | 1 | 4 | 1 | 9 | |
| Contraception | D003267 | 3 | 1 | 1 | 1 | 2 | 8 | ||
| Bacterial conjunctivitis | D003234 | EFO_1000829 | H10.0 | — | 1 | 4 | 3 | — | 8 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 4 | — | 2 | 1 | — | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 11 | 8 | — | 2 | 17 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | 7 | 8 | — | — | 9 | |
| Community-acquired infections | D017714 | — | 2 | 3 | — | — | 5 | ||
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 2 | 1 | 2 | — | — | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 2 | — | — | 4 |
| Extensively drug-resistant tuberculosis | D054908 | — | 4 | 4 | — | — | 4 | ||
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 3 | — | — | 3 |
| Keratitis | D007634 | H16 | — | — | 3 | — | — | 3 | |
| Lymphoma | D008223 | C85.9 | 1 | — | 1 | — | 1 | 3 | |
| Abdominal abscess | D018784 | EFO_1001753 | — | — | 1 | — | 1 | 2 |
Show 32 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | 11 | 1 | — | — | — | 12 | ||
| Neoplasms | D009369 | C80 | 2 | 1 | — | — | 1 | 4 | |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 1 | — | — | — | 4 |
| Cholangitis | D002761 | K83.0 | — | 1 | — | — | — | 1 | |
| Corneal ulcer | D003320 | H16.0 | — | 1 | — | — | — | 1 | |
| Metrorrhagia | D008796 | HP_0100608 | N92.1 | — | 1 | — | — | — | 1 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | 1 | — | — | — | 1 |
| Meningeal tuberculosis | D014390 | A17.0 | — | 1 | — | — | — | 1 | |
| Graft vs host disease | D006086 | D89.81 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | 1 | 4 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 4 | — | — | — | — | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 4 | — | — | — | — | 4 |
| Hepatitis c | D006526 | B19.2 | 4 | — | — | — | — | 4 | |
| Therapeutic equivalency | D013810 | 4 | — | — | — | — | 4 | ||
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 4 | — | — | — | — | 4 |
| Asthma | D001249 | EFO_0000270 | J45 | 3 | — | — | — | — | 3 |
| Dyslipidemias | D050171 | HP_0003119 | 3 | — | — | — | — | 3 | |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | 1 | — | — | — | 1 | 2 |
| Cardiovascular abnormalities | D018376 | EFO_0003848 | 1 | — | — | — | 1 | 2 |
Show 47 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | — | — | — | — | 2 | 2 |
| Pathologic dilatation | D004108 | — | — | — | — | 2 | 2 | ||
| Keratoconus | D007640 | EFO_0004223 | H18.6 | — | — | — | — | 2 | 2 |
| Regeneration | D012038 | — | — | — | — | 2 | 2 | ||
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 2 | 2 |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 | |
| Mycoplasma pneumonia | D011019 | EFO_0007387 | J15.7 | — | — | — | — | 1 | 1 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 1 | 1 |
| Chemical and drug induced liver injury | D056486 | — | — | — | — | 1 | 1 | ||
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NORTRIPTYLINE |
| INN | nortriptyline |
| Description | Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as a drug metabolite, an antidepressant, an adrenergic uptake inhibitor, an analgesic, an antineoplastic agent and an apoptosis inducer. It is an organic tricyclic compound and a secondary amine. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene. |
| Classification | Small molecule |
| Drug class | antidepressants (dibenzol[a,d]cycloheptane derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CNCCC=C1c2ccccc2CCc2ccccc21 |
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
KCNJ10
KCNJ10
KCNJ6
KCNJ6
KCNJ5
KCNJ5
Organism
Homo sapiens
Gene name
KCNJ10
Gene synonyms
NCBI Gene ID
Protein name
ATP-sensitive inward rectifier potassium channel 10
Protein synonyms
ATP-dependent inwardly rectifying potassium channel Kir4.1, glial ATP-dependent inwardly rectifying potassium channel KIR4.1, Inward rectifier K(+) channel Kir1.2, inward rectifier K+ channel KIR1.2, Potassium channel, inwardly rectifying subfamily J member 10, potassium voltage-gated channel subfamily J member 10
Uniprot ID
Mouse ortholog
Kcnj10 (16513)
ATP-sensitive inward rectifier potassium channel 10 (Q9JM63)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Nortriptyline hydrochloride, Pamelor
Adverse Events
Top Adverse Reactions
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7,366 adverse events reported
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