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Odanacatib
Odanacatib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cathepsin K. In addition, it is known to target cathepsin S and cathepsin Z.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.0624——12
Postmenopausal osteoporosisD015663EFO_0003854—12——3
Breast neoplasmsD001943EFO_0003869C50—11——2
Prostatic neoplasmsD011471C61——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vitamin d deficiencyD014808EFO_0003762E55—1———1
Bone diseasesD001847M89.9—1———1
OsteoarthritisD010003EFO_0002506M15-M19—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatic insufficiencyD0485501————1
Renal insufficiencyD051437HP_0000083N191————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameODANACATIB
INNodanacatib
Description
Odanacatib (INN; codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis. It is an inhibitor of cathepsin K, an enzyme involved in bone resorption.
Classification
Small molecule
Drug classcathespin inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1
Identifiers
PDB—
CAS-ID603139-19-1
RxCUI—
ChEMBL IDCHEMBL481611
ChEBI ID—
PubChem CID10152654
DrugBankDB06670
UNII IDN673F6W2VH (ChemIDplus, GSRS)
Target
Agency Approved
CTSK
CTSK
Organism
Homo sapiens
Gene name
CTSK
Gene synonyms
CTSO, CTSO2
NCBI Gene ID
1513
Protein name
cathepsin K
Protein synonyms
Cathepsin O, cathepsin O1, Cathepsin O2, Cathepsin X
Uniprot ID
Q6FHS6
Mouse ortholog
Ctsk (13038)
cathepsin K (P55097)
Alternate
CTSS
CTSS
CTSZ
CTSZ
Organism
Homo sapiens
Gene name
CTSS
Gene synonyms
NCBI Gene ID
1520
Protein name
cathepsin S
Protein synonyms
Uniprot ID
P25774
Mouse ortholog
Ctss (13040)
cathepsin S (O70370)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 705 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3 adverse events reported
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