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Olinciguat
Olinciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sickle cell anemiaD000755EFO_0000697D57—1———1
Esophageal achalasiaD004931HP_0002571K22.0—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—4————4
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOLINCIGUAT
INNolinciguat
Description
Olinciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1.
Classification
Small molecule
Drug classguanaline cyclase activators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NC(=O)[C@](O)(CNc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)ncc1F)C(F)(F)F
Identifiers
PDB—
CAS-ID1628732-62-6
RxCUI—
ChEMBL IDCHEMBL4297616
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDPD5F4ZXD21 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GUCY1B1
GUCY1B1
Organism
Homo sapiens
Gene name
GUCY1B1
Gene synonyms
GUC1B3, GUCSB3, GUCY1B3
NCBI Gene ID
2983
Protein name
guanylate cyclase soluble subunit beta-1
Protein synonyms
GCS-beta-1, GCS-beta-3, guanylate cyclase 1, soluble, beta 3, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit
Uniprot ID
Q86WY5
Mouse ortholog
Gucy1b1 (54195)
guanylate cyclase soluble subunit beta-1 (O54865)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 28 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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