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Omeprazole
Konvomep, Prilosec, Talicia, Yosprala, Zegerid (omeprazole) is a small molecule pharmaceutical. Omeprazole was first approved as Prilosec on 1989-09-14. It is used to treat duodenal ulcer, esophagitis, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against potassium-transporting ATPase alpha chain 1. In addition, it is known to target chloride channel protein 2.
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Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Prilosec (generic drugs available since 2002-11-01, discontinued: Prilosec)
Combinations
Konvomep, Talicia, Zegerid (generic drugs available since 2002-11-01, discontinued: Yosprala, Zegerid)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amoxicillin
+
Clarithromycin
+
Omeprazole
Tradename
Company
Number
Date
Products
OMEPRAZOLE AND CLARITHROMYCIN AND AMOXICILLINCumberland PharmaceuticalsN-050824 DISCN2011-02-08
1 products, RLD
Hide discontinued
Amoxicillin
+
Omeprazole magnesium
+
Rifabutin
Tradename
Company
Number
Date
Products
TALICIARedHill BiopharmaN-213004 RX2019-11-01
1 products, RLD, RS
Aspirin
+
Omeprazole
Tradename
Company
Number
Date
Products
YOSPRALAGenus LifesciencesN-205103 DISCN2016-09-14
2 products, RLD
Hide discontinued
Magnesium hydroxide
+
Omeprazole
+
Sodium bicarbonate
Tradename
Company
Number
Date
Products
ZEGERIDSantarusN-021850 DISCN2006-03-24
2 products
MAGNESIUM HYDROXIDE AND OMEPRAZOLE AND SODIUM BICARBONATESantarusN-022456 DISCN2009-12-04
2 products
Hide discontinued
Omeprazole
Tradename
Company
Number
Date
Products
OMEPRAZOLEDexcel PharmaN-209400 OTC2017-07-05
1 products, RLD, RS
OMEPRAZOLEDexcel PharmaN-022032 OTC2007-12-04
1 products, RLD, RS
Show 1 discontinued
Omeprazole
+
Sodium bicarbonate
Tradename
Company
Number
Date
Products
KONVOMEPAzurityN-213593 RX2022-08-30
1 products, RLD, RS
ZEGERID OTCRiley Consumer Care HoldingsN-022281 OTC2009-12-01
1 products, RLD, RS
ZEGERID OTCRiley Consumer Care HoldingsN-022283 OTC2013-06-17
1 products, RLD, RS
ZEGERIDSalix PharmaceuticalsN-021636 RX2004-06-15
2 products, RLD
ZEGERIDSalix PharmaceuticalsN-021849 RX2006-02-27
2 products, RLD, RS
Omeprazole magnesium
Tradename
Company
Number
Date
Products
PRILOSEC OTCAstraZenecaN-021229 OTC2003-06-20
1 products, RLD, RS
PRILOSECCovis PharmaN-022056 RX2008-03-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
konvomepNew Drug Application2022-08-30
omeprazoleNew Drug Application2023-06-06
prilosec otcNew Drug Application2023-05-03
taliciaNew Drug Application2021-10-05
yospralaNew Drug Application2021-08-31
zegerid otcANDA2022-12-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
duodenal ulcerEFO_0004607D004381K26
esophagitisHP_0100633D004941K20
gastroesophageal refluxEFO_0003948D005764K21
heartburn—D006356R12
helicobacter infectionsEFO_1000961D016481—
stomach ulcer—D013276K25
zollinger-ellison syndrome—D015043E16.4
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Omeprazole / Sodium Bicarbonate, Konvomep, Azurity
107513332039-07-16DP
111034922039-07-16DP
116334782039-07-16DP
Omeprazole, Omeprazole, Dexcel
100764942036-12-08DP
108354882036-12-08DP
Amoxicillin / Omeprazole Magnesium / Rifabutin, Talicia, Redhill
90502632034-02-12DPU-2660
94984452034-02-12DPU-2660
96038062034-02-12DPU-2660
102386062034-02-12DP
111351722034-02-12DPU-2660
Aspirin / Omeprazole, Yosprala, Genus Lifesciences
95392142033-03-13U-1902
99872312033-01-02U-2324
69269072023-02-28DPU-1902
82067412023-02-28DPU-1902
Omeprazole, Omeprazole, Dexcel Pharma
90233912025-08-16DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BC: Proton pump inhibitors for peptic ulcer and gord
— A02BC01: Omeprazole
— A02BD: Combinations for eradication of helicobacter pylori
— A02BD01: Omeprazole, amoxicillin and metronidazole
— A02BD05: Omeprazole, amoxicillin and clarithromycin
— A02BD16: Omeprazole, amoxicillin and rifabutin
HCPCS
No data
Clinical
Clinical Trials
360 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—84——2389
Gastroesophageal refluxD005764EFO_0003948K216458729
InfectionsD007239EFO_00005441137314
Drug interactionsD0043476——118
Peptic ulcerD010437HP_0004398K271—1518
Rheumatoid arthritisD001172EFO_0000685M06.95—11—7
Coronary artery diseaseD003324I25.1——1416
Peptic ulcer hemorrhageD010438—12216
DyspepsiaD004415EFO_0008533K30111115
Laryngopharyngeal refluxD057045EFO_1001355———5—5
Show 37 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GastritisD005756EFO_0000217K29.7—22—14
Peptic esophagitisD004942EFO_10010951—2——3
Human experimentationD006805——3——3
Helicobacter infectionsD016481EFO_1000961——2——2
Stomach neoplasmsD013274EFO_0003897C16——2——2
Exocrine pancreatic insufficiencyD010188K86.81—11——2
Myocardial infarctionD009203EFO_0000612I21——1——1
Percutaneous coronary interventionD062645——1——1
Relapsing-remitting multiple sclerosisD020529EFO_0003929——1——1
NeurocysticercosisD020019——1——1
Show 9 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C80141———15
Type 2 diabetes mellitusD003924EFO_0001360E1121———3
Breast neoplasmsD001943EFO_0003869C5021———3
Prostatic neoplasmsD011471C6111———2
Castration-resistant prostatic neoplasmsD06412911———2
LymphomaD008223C85.9—2———2
Squamous cell carcinoma of head and neckD000077195—2———2
Liver diseasesD008107EFO_0001421K70-K77—1———1
Insulin resistanceD007333EFO_0002614—1———1
Fatty liverD005234—1———1
Show 13 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B205————5
PharmacokineticsD0105994————4
Alzheimer diseaseD000544EFO_0000249F033————3
PsoriasisD011565EFO_0000676L402————2
Atopic dermatitisD003876EFO_0000274L202————2
Chronic hepatitis bD019694EFO_0004197B18.12————2
Clostridium infectionsD003015EFO_1000874A05.21———12
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.92————2
MelanomaD0085451————1
Platelet aggregationD010974GO_00705271————1
Show 24 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.0————55
Covid-19D000086382U07.1————11
Critical illnessD016638————11
B-cell lymphoma marginal zoneD018442C88.4————11
Bile refluxD001655EFO_1000838————11
Liver cirrhosisD008103EFO_0001422K74.0————11
Knee osteoarthritisD020370EFO_0004616M17————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOMEPRAZOLE
INNomeprazole
Description
6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole is a member of benzimidazoles and a sulfoxide.
Classification
Small molecule
Drug classantiulcer agents (benzimidazole derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1
Identifiers
PDB—
CAS-ID73590-58-6
RxCUI7646
ChEMBL IDCHEMBL1503
ChEBI ID77260
PubChem CID4594
DrugBankDB00338
UNII IDKG60484QX9 (ChemIDplus, GSRS)
Target
Agency Approved
ATP4A
ATP4A
Organism
Homo sapiens
Gene name
ATP4A
Gene synonyms
NCBI Gene ID
495
Protein name
potassium-transporting ATPase alpha chain 1
Protein synonyms
ATPase H+/K+ transporting alpha subunit, ATPase, H+/K+ exchanging, alpha polypeptide, ATPase, H+/K+ transporting, alpha polypeptide, epididymis secretory sperm binding protein, Gastric H(+)/K(+) ATPase subunit alpha, gastric H+/K+ ATPase alpha subunit, gastric H,K-ATPase catalytic subunit, gastric hydrogen-potassium ATPase, Proton pump
Uniprot ID
P20648
Mouse ortholog
Atp4a (11944)
potassium-transporting ATPase alpha chain 1 (Q9CV46)
Alternate
CLCN2
CLCN2
Organism
Homo sapiens
Gene name
CLCN2
Gene synonyms
NCBI Gene ID
1181
Protein name
chloride channel protein 2
Protein synonyms
chloride channel 2, chloride channel, voltage-sensitive 2
Uniprot ID
P51788
Mouse ortholog
Clcn2 (12724)
chloride channel protein 2 (Q9WUJ9)
Variants
Clinical Variant
No data
Financial
Prilosec - AstraZeneca
$
€
£
₣
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,818 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,122 adverse events reported
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