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Onametostat
Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D461————1
NeoplasmsD009369C801————1
Non-hodgkin lymphomaD008228C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameONAMETOSTAT
INNonametostat
Description
Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5.
Classification
Small molecule
Drug classenzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1nc2cc(CC[C@H]3C[C@@H](n4ccc5c(N)ncnc54)[C@H](O)[C@@H]3O)ccc2cc1Br
Identifiers
PDB—
CAS-ID2086772-26-9
RxCUI—
ChEMBL IDCHEMBL4249337
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDN8VKI8FPW0 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PRMT5
PRMT5
Organism
Homo sapiens
Gene name
PRMT5
Gene synonyms
HRMT1L5, IBP72, JBP1, SKB1
NCBI Gene ID
10419
Protein name
protein arginine N-methyltransferase 5
Protein synonyms
72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, HMT1 hnRNP methyltransferase-like 5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs
Uniprot ID
O14744
Mouse ortholog
Prmt5 (27374)
protein arginine N-methyltransferase 5 (Q8CIG8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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