Skip to content
Onatasertib
Onatasertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase mTOR. In addition, it is known to target macrophage colony-stimulating factor 1 receptor and vascular endothelial growth factor receptor 3.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228921———2
Large b-cell lymphoma diffuseD016403C83.321———2
Liver neoplasmsD008113EFO_1001513C22.012———2
NeoplasmsD009369C8012———2
Multiple myelomaD009101C90.011———1
GlioblastomaD005909EFO_000051511———1
Neuroendocrine tumorsD018358EFO_1001901D3A.811———1
Uterine cervical neoplasmsD002583—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameONATASERTIB
INNonatasertib
Description
Onatasertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase mTOR. In addition, it is known to target macrophage colony-stimulating factor 1 receptor and vascular endothelial growth factor receptor 3.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1CC[C@H](N2C(=O)CNc3ncc(-c4ccc(C(C)(C)O)nc4)nc32)CC1
Identifiers
PDB—
CAS-ID1228013-30-6
RxCUI—
ChEMBL IDCHEMBL3586404
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDI8RA3543SY (ChemIDplus, GSRS)
Target
Agency Approved
MTOR
MTOR
Organism
Homo sapiens
Gene name
MTOR
Gene synonyms
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
NCBI Gene ID
2475
Protein name
serine/threonine-protein kinase mTOR
Protein synonyms
FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, Mammalian target of rapamycin, Mechanistic target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), mTOR, Rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, Rapamycin target protein 1
Uniprot ID
Q9Y4I3
Mouse ortholog
Mtor (56717)
serine/threonine-protein kinase mTOR (Q9JLN9)
Alternate
CSF1R
CSF1R
FLT4
FLT4
Organism
Homo sapiens
Gene name
CSF1R
Gene synonyms
FMS
NCBI Gene ID
1436
Protein name
macrophage colony-stimulating factor 1 receptor
Protein synonyms
CD115, CD115 antigen, CSF-1 receptor, CSF-1-R, CSF-1R, FMS proto-oncogene, M-CSF-R, macrophage colony stimulating factor I receptor, McDonough feline sarcoma viral (v-fms) oncogene homolog, Proto-oncogene c-Fms
Uniprot ID
Q86VW7
Mouse ortholog
Csf1r (12978)
macrophage colony-stimulating factor 1 receptor (Q9DBH9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 10 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details