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Opipramol
Opipramol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target sigma non-opioid intracellular receptor 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA05: Opipramol
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
SchizophreniaD012559EFO_0000692F20——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Substance-related disordersD019966EFO_0003890F131————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10————11
Cardiovascular diseasesD002318EFO_0000319I98————11
Heart disease risk factorsD000082742————11
Sleep apnea syndromesD012891EFO_0003877G47.3————11
Temporomandibular joint disordersD013705M26.6————11
Sleep bruxismD020186G47.63————11
Sleep wake disordersD012893G47————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOPIPRAMOL
INNopipramol
Description
2-[4-[3-(11-benzo[b][1]benzazepinyl)propyl]-1-piperazinyl]ethanol is a dibenzoazepine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1
Identifiers
PDB—
CAS-ID315-72-0
RxCUI7674
ChEMBL IDCHEMBL370753
ChEBI ID—
PubChem CID9417
DrugBankDB12930
UNII IDD23ZXO613C (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SIGMAR1
SIGMAR1
Organism
Homo sapiens
Gene name
SIGMAR1
Gene synonyms
OPRS1, SRBP
NCBI Gene ID
10280
Protein name
sigma non-opioid intracellular receptor 1
Protein synonyms
Aging-associated gene 8 protein, hSigmaR1, SIG-1R, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R, SR-BP, SR31747 binding protein 1, SR31747-binding protein
Uniprot ID
Q99720
Mouse ortholog
Sigmar1 (18391)
sigma non-opioid intracellular receptor 1 (O55242)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 320 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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422 adverse events reported
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