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Otenabant
Otenabant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cannabinoid receptor 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9515——10
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Hepatic insufficiencyD0485501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOTENABANT
INNotenabant
Description
Otenabant (CP-945,598) is a drug which acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.
Classification
Small molecule
Drug classcannabinol derivatives: CB (e.g., CB, CB2, etc.) cannabinoid receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCNC1(C(N)=O)CCN(c2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1
Identifiers
PDB—
CAS-ID686344-29-6
RxCUI—
ChEMBL IDCHEMBL562668
ChEBI ID—
PubChem CID10052040
DrugBankDB11745
UNII IDJ8211Y53EF (ChemIDplus, GSRS)
Target
Agency Approved
CNR1
CNR1
Organism
Homo sapiens
Gene name
CNR1
Gene synonyms
CNR
NCBI Gene ID
1268
Protein name
cannabinoid receptor 1
Protein synonyms
CANN6, cannabinoid receptor 1 (brain), central cannabinoid receptor
Uniprot ID
Q9UNN0
Mouse ortholog
Cnr1 (12801)
cannabinoid receptor 1 (Q5SF33)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 59 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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