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Palovarotene
Palovarotene is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against retinoic acid receptor gamma.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M09: Other drugs for disorders of the musculo-skeletal system in atc
— M09A: Other drugs for disorders of the musculo-skeletal system in atc
— M09AX: Other drugs for disorders of the musculo-skeletal system in atc
— M09AX11: Palovarotene
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myositis ossificansD009221M61.1142——7
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple hereditary exostosesD005097Q78.6—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.121————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePALOVAROTENE
INNpalovarotene
Description
Palovarotene is a stilbenoid.
Classification
Small molecule
Drug classarotinoid derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21
Identifiers
PDB—
CAS-ID410528-02-8
RxCUI—
ChEMBL IDCHEMBL2105648
ChEBI ID—
PubChem CID10295295
DrugBankDB12320
UNII ID28K6I5M16G (ChemIDplus, GSRS)
Target
Agency Approved
RARG
RARG
Organism
Homo sapiens
Gene name
RARG
Gene synonyms
NR1B3
NCBI Gene ID
5916
Protein name
retinoic acid receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group B member 3, RAR-gamma
Uniprot ID
Q9UJ38
Mouse ortholog
Rarg (19411)
retinoic acid receptor gamma (P18911)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 183 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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