Pamidronic acid
Aredia (pamidronic acid) is a small molecule pharmaceutical. Pamidronic acid was first approved as Aredia on 1991-10-31. It is used to treat extramammary paget disease, hypercalcemia, osteolysis, and postmenopausal osteoporosis in the USA. The pharmaceutical is active against farnesyl pyrophosphate synthase.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pamidronate disodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PAMIDRONATE DISODIUM | Hikma Pharmaceuticals | N-021113 RX | 2002-03-04 | 2 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| pamidronate disodium | ANDA | 2021-04-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| extramammary paget disease | — | D010145 | — |
| hypercalcemia | HP_0003072 | D006934 | E83.52 |
| osteolysis | — | D010014 | M89.5 |
| postmenopausal osteoporosis | EFO_0003854 | D015663 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
576 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum hemorrhage | D006473 | O72 | 5 | 5 | 8 | 11 | 41 | 69 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 9 | 7 | — | 2 | 11 | 28 |
| Autism spectrum disorder | D000067877 | F84.0 | 7 | 13 | 2 | 1 | 3 | 25 | |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 3 | 3 | 4 | 7 | 18 |
| Induced labor | D007751 | 1 | 3 | 2 | 4 | 5 | 15 | ||
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 2 | 7 | — | 2 | 2 | 13 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | — | 1 | 8 | 10 |
| Uterine inertia | D014593 | EFO_1001863 | O62.2 | — | — | — | 6 | 2 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 4 | — | 2 | 2 | 8 |
| Cesarean section | D002585 | 2 | 1 | 1 | 1 | 3 | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 16 | 2 | 1 | — | 33 | 52 | ||
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 5 | 12 | 3 | — | — | 19 |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | 4 | 8 | 2 | — | 2 | 11 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 8 | 1 | — | — | 8 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | — | 1 | — | 5 | 7 |
| Cocaine-related disorders | D019970 | F14 | 2 | 4 | 1 | — | 1 | 6 | |
| Smoking | D012907 | EFO_0003768 | F17 | 1 | 1 | 1 | — | — | 2 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | — | 1 | — | 1 | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 1 | — | — | 1 |
| Pelvic pain | D017699 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 2 | 5 | — | — | — | 7 |
| Social cognition | D000083282 | 5 | 1 | — | — | — | 6 | ||
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 5 | 1 | — | — | — | 5 |
| Frontotemporal dementia | D057180 | G31.0 | 1 | 2 | — | — | 1 | 4 | |
| Postoperative hemorrhage | D019106 | 1 | 1 | — | — | 2 | 3 | ||
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 2 | — | — | 1 | 3 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 2 | — | — | 1 | 3 |
| Hyperphagia | D006963 | R63.2 | — | 2 | — | — | — | 2 | |
| Emotional intelligence | D056348 | — | 1 | — | — | 1 | 2 | ||
| Inflammation | D007249 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychotic disorders | D011618 | F20.81 | 3 | — | — | — | 2 | 5 | |
| Social psychology | D011593 | 3 | — | — | — | — | 3 | ||
| Pain | D010146 | EFO_0003843 | R52 | 2 | — | — | — | 1 | 3 |
| High-risk pregnancy | D018566 | 1 | — | — | — | 2 | 3 | ||
| Borderline personality disorder | D001883 | HP_0012076 | F60.3 | 1 | — | — | — | 2 | 3 |
| Emotions | D004644 | 1 | — | — | — | 1 | 2 | ||
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 2 | — | — | — | — | 2 |
| Antisocial personality disorder | D000987 | F60.2 | 1 | — | — | — | 1 | 2 | |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | — | — | 1 | 2 |
| Overweight | D050177 | E66.3 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstetric labor complications | D007744 | — | — | — | — | 3 | 3 | ||
| Breast feeding | D001942 | — | — | — | — | 2 | 2 | ||
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | — | — | — | 2 | 2 |
| Anesthesia | D000758 | — | — | — | — | 2 | 2 | ||
| Mastitis | D008413 | EFO_1001034 | N61 | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | A41.9 | — | — | — | — | 1 | 1 | |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | 1 | |
| Learning disabilities | D007859 | F81.9 | — | — | — | — | 1 | 1 | |
| Essential hypertension | D000075222 | I10 | — | — | — | — | 1 | 1 | |
| Asphyxia | D001237 | R09.01 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PAMIDRONIC ACID |
| INN | pamidronic acid |
| Description | Pamidronate is a phosphonoacetic acid. |
| Classification | Small molecule |
| Drug class | calcium metabolism regulators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NCCC(O)(P(=O)(O)O)P(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 40391-99-9 |
| RxCUI | 11473 |
| ChEMBL ID | CHEMBL834 |
| ChEBI ID | — |
| PubChem CID | 4674 |
| DrugBank | DB00282 |
| UNII ID | OYY3447OMC (ChemIDplus, GSRS) |
Target
Agency Approved
FDPS
FDPS
Organism
Homo sapiens
Gene name
FDPS
Gene synonyms
FPS, KIAA1293
NCBI Gene ID
Protein name
farnesyl pyrophosphate synthase
Protein synonyms
(2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase, FPP synthase, FPP synthetase, Geranyltranstransferase
Uniprot ID
Mouse ortholog
Fdps (110196)
farnesyl pyrophosphate synthase (Q920E5)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,517 adverse events reported
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