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Natpara, Natpar(parathyroid hormone)
Natpar, Natpara (parathyroid hormone) is a protein pharmaceutical. Parathyroid hormone was first approved as Natpara on 2015-01-23. It is used to treat hypocalcemia and hypoparathyroidism in the USA. It has been approved in Europe to treat hypoparathyroidism. It is known to target prolactin-releasing peptide receptor, parathyroid hormone 2 receptor, and parathyroid hormone/parathyroid hormone-related peptide receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Natpara
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Parathyroid hormone
Tradename
Proper name
Company
Number
Date
Products
Natparaparathyroid hormoneTakedaN-125511 RX2015-01-23
4 products
Labels
FDA
EMA
Brand Name
Status
Last Update
natpara (parathyroid hormone)Biologic Licensing Application2020-07-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypocalcemiaHP_0002901D006996E83.51
hypoparathyroidism—D007011E20
Agency Specific
FDA
EMA
Expiration
Code
parathyroid hormone, Natpara, Takeda Pharmaceuticals U.S.A., Inc.
2122-01-23Orphan excl.
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05A: Parathyroid hormones and analogues
— H05AA: Parathyroid hormones and analogues
— H05AA03: Parathyroid hormone
HCPCS
No data
Clinical
Clinical Trials
80 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.04773222
Shoulder fracturesD012784S42.9———1—1
Back painD001416HP_0003418M54———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypoparathyroidismD007011E20358—318
HypercalcemiaD006934E83.521—1—24
Thyroid diseasesD013959HP_0000820E00-E07——1—12
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Digeorge syndromeD004062D82.122———3
Myeloid leukemia acuteD015470C92.0—1———1
Primary myelofibrosisD055728D47.4—1———1
LymphomaD008223C85.9—1———1
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0—1———1
B-cell chronic lymphocytic leukemiaD015451C91.1—1———1
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—1———1
Hodgkin diseaseD006689C81—1———1
Aplastic anemiaD000741HP_0001915D61.9—1———1
PhenylketonuriasD010661E70.011———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperparathyroidismD006961EFO_0008506E21.33———36
HypocalcemiaD006996HP_0002901E83.511———23
Endocrine bone diseasesD0018492————2
Postmenopausal osteoporosisD015663EFO_00038541————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Primary hyperparathyroidismD049950EFO_0008519E21.0————55
Thyroid neoplasmsD013964EFO_0003841————44
Parathyroid neoplasmsD010282————33
Parathyroid diseasesD010279E21.5————33
Drug-related side effects and adverse reactionsD064420T88.7————22
Intraoperative monitoringD016343————11
Papillary thyroid cancerD000077273————11
Lymphatic metastasisD008207EFO_1001364————11
Critical illnessD016638————11
Renal insufficiencyD051437HP_0000083N19————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePARATHYROID HORMONE
INNparathyroid hormone
Description
Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates the serum calcium concentration through its effects on bone, kidney, and intestine.
Classification
Protein
Drug class—
Image (chem structure or protein)PARATHYROID HORMONE
Structure (InChI/SMILES or Protein Sequence)
>3FFD:A|Monoclonal antibody, heavy chain, Fab fragment EVQLVESGGDLVKPGGSLKLSCAASGFTFSSYGMSWIRQTPDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY LQMSSLKSEDTAMFYCARQTTMTYFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWN SGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIEPA >3FFD:B|Monoclonal antibody, light chain, Fab fragment QLVLTQSSSASFSLGASAKLTCTLSSQHSTYTIEWYQQQPLKPPKYVMDLKQDGSHSTGDGIPDRFSGSSSGADRYLSIS NIQPEDEAMYICGVGDTIKEQFVYVFGGGTKVTVLGEPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKAN GTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL
Identifiers
PDB1BL1, 1BWX, 1BZG, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1M5N, 1ZWA, 1ZWB, 1ZWC, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M, 3FFD, 3H3G, 3L2J, 4YD8, 4Z8J, 5EMB, 6FJ3, 6NBF, 6NBH, 6NBI, 6XT9, 7F16, 7UZO, 7UZP, 7VVJ, 7VVK, 7VVL, 7VVM, 7VVN, 7VVO, 8D51, 8D52, 8FLQ, 8FLR, 8FLS, 8FLT, 8FLU, 8GW8, 8HA0, 8HAF, 8HAO
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL2108078
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDN19A0T0E5J (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PRLHR
PRLHR
PTH2R
PTH2R
PTH1R
PTH1R
Organism
Homo sapiens
Gene name
PRLHR
Gene synonyms
GPR10, GR3
NCBI Gene ID
2834
Protein name
prolactin-releasing peptide receptor
Protein synonyms
G-protein coupled receptor 10, hGR3, prRP receptor
Uniprot ID
Q5VXR9
Mouse ortholog
Prlhr (226278)
prolactin-releasing peptide receptor (Q6VMN6)
Variants
Clinical Variant
No data
Financial
Natpara - Takeda
$
€
£
₣
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Natpara - Shire
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 54,563 documents
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Safety
Black-box Warning
Black-box warning for: Natpara (parathyroid hormone)
Adverse Events
Top Adverse Reactions
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12,837 adverse events reported
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