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Paricalcitol
Zemplar (paricalcitol) is a small molecule pharmaceutical. Paricalcitol was first approved as Zemplar on 1998-04-17. It is used to treat hyperparathyroidism in the USA. The pharmaceutical is active against vitamin D3 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
endocrine system diseasesD004700
Trade Name
FDA
EMA
Zemplar (generic drugs available since 2011-07-27)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Paricalcitol
Tradename
Company
Number
Date
Products
ZEMPLARAbbVieN-020819 RX1998-04-17
3 products, RLD, RS
ZEMPLARAbbVieN-021606 RX2005-05-26
2 products, RLD
PARICALCITOLACCORD HLTHCAREN-207174 RX2016-02-04
3 products
PARICALCITOLHikma PharmaceuticalsN-205917 RX2014-11-18
3 products
PARICALCITOLHospiraN-201657 RX2014-10-21
3 products
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
paricalcitolANDA2023-02-27
zemplarNew Drug Application2021-04-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hyperparathyroidismEFO_0008506D006961E21.3
Agency Specific
FDA
EMA
Expiration
Code
PARICALCITOL, ZEMPLAR, ABBVIE
2023-10-18ODE*, ODE-125
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05B: Anti-parathyroid agents
— H05BX: Other anti-parathyroid agents in atc
— H05BX02: Paricalcitol
HCPCS
Code
Description
J2501
Injection, paricalcitol, 1 mcg
Clinical
Clinical Trials
329 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C25926413671
Exocrine pancreatic insufficiencyD010188K86.8124148834
Chronic pancreatitisD050500EFO_0000342K86.131241020
Cystic fibrosisD003550EFO_0000390E841284418
PancreatitisD010195EFO_0000278K8532111117
Diabetes mellitusD003920EFO_0000400E08-E13———279
Pancreatic pseudocystD010192HP_0005206K86.3———145
Irritable bowel syndromeD043183EFO_0000555K58———1—1
Pancreas transplantationD016035———1—1
Celiac diseaseD002446EFO_0001060K90.0———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E1016218—4883
Pancreatic fistulaD010185—12—1114
SteatorrheaD045602112——4
Chronic kidney failureD007676EFO_0003884N18.6——1—23
PancreatectomyD010180EFO_0002581——2—13
Circulating neoplastic cellsD009360——1—12
SepsisD018805A41.9—11——1
Child nutrition disordersD015362—11——1
Malabsorption syndromesD008286EFO_0009554K90——1——1
EructationD004884R14.2——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperglycemiaD006943HP_0003074R73.9—1——34
Pancreatic ductal carcinomaD02144111——23
Postoperative complicationsD011183—1———1
Short bowel syndromeD012778—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CystsD0035601———45
HypoglycemiaD007003HP_0001943E16.21———12
Anastomotic leakD0578681————1
Interventional ultrasonographyD0180841————1
And serous mucinous cystic neoplasmsD0182971————1
Graft pancreatitisD0555891————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic cystD010181HP_0001737K86.2————99
Pancreatic diseasesD010182K86.9————66
Type 2 diabetes mellitusD003924EFO_0001360E11————55
Acute necrotizing pancreatitisD019283————44
AdenocarcinomaD000230————44
OverweightD050177E66.3————22
PainD010146EFO_0003843R52————22
GallstonesD042882EFO_0004210————22
Endoscopic retrograde cholangiopancreatographyD002760————22
MalnutritionD044342EFO_0008572E40-E46————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePARICALCITOL
INN—
Description
Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.
Classification
Small molecule
Drug classvitamin D analogs
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](/C=C/[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C3C[C@@H](O)C[C@H](O)C3)CCC[C@@]21C)C(C)(C)O
Identifiers
PDB—
CAS-ID131918-61-1
RxCUI73710
ChEMBL IDCHEMBL1200622
ChEBI ID7931
PubChem CID5281104
DrugBankDB00910
UNII ID—
Target
Agency Approved
VDR
VDR
Organism
Homo sapiens
Gene name
VDR
Gene synonyms
NR1I1
NCBI Gene ID
7421
Protein name
vitamin D3 receptor
Protein synonyms
1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor
Uniprot ID
Q5PSV3
Mouse ortholog
Vdr (22337)
vitamin D3 receptor (Q922X0)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Zemplar - AbbVie
$
€
£
₣
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,628 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,163 adverse events reported
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