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Pentagastrin
Peptavlon (pentagastrin) is a small molecule pharmaceutical. Pentagastrin was first approved as Peptavlon on 1982-01-01. It is known to target cholecystokinin receptor type A and gastrin/cholecystokinin type B receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pentagastrin
Tradename
Company
Number
Date
Products
PEPTAVLONWyethN-017048 DISCN1982-01-01
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
pentagastrinunapproved drug other2012-06-19
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CG: Gastric secretion test diagnostic agents
— V04CG04: Pentagastrin
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SyphilisD013587EFO_0007504A53.91225—9
InfectionsD007239EFO_0000544——11—2
Staphylococcus aureusD013211NCBITaxon_1280———1—1
Urinary tract infectionsD014552EFO_0003103N39.0———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PneumoniaD011014EFO_0003106J18——2—13
SepsisD018805A41.9——2——2
YawsD015001EFO_0007548A66——1——1
Treponemal infectionsD014211EFO_1001217——1——1
MalnutritionD044342EFO_0008572E40-E46——1——1
Microbial drug resistanceD004352——1——1
EndocarditisD004696EFO_0000465I33——1——1
Bacterial infectionsD001424A49——1——1
Neonatal sepsisD000071074HP_0040187——1——1
HivD006678O98.7——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatic heart diseaseD012214EFO_1001161I09.9—2——13
Heart diseasesD006331EFO_0003777I51.9—1———1
PsoriasisD011565EFO_0000676L40—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20————11
NeurosyphilisD009494EFO_0007339A50.4————11
TonsillitisD014069HP_0011110J03————11
Streptococcal infectionsD013290EFO_1001476————11
PharyngitisD010612R07.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePENTAGASTRIN
INNpentagastrin
Description
Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Identifiers
PDB—
CAS-ID5534-95-2
RxCUI7993
ChEMBL IDCHEMBL1328
ChEBI ID—
PubChem CID9853654
DrugBankDB00183
UNII IDEF0NX91490 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CCKAR
CCKAR
CCKBR
CCKBR
Organism
Homo sapiens
Gene name
CCKAR
Gene synonyms
CCKRA
NCBI Gene ID
886
Protein name
cholecystokinin receptor type A
Protein synonyms
CCK-A receptor, CCK-AR, CCK1-R, cholecystokinin type-A receptor, Cholecystokinin-1 receptor
Uniprot ID
P32238
Mouse ortholog
Cckar (12425)
cholecystokinin receptor type A (Q9DBV6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,933 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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448 adverse events reported
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