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Pentazocine
Talacen, Talwin (pentazocine) is a small molecule pharmaceutical. Pentazocine was first approved as Talwin compound on 1982-01-01. It is used to treat pain in the USA. The pharmaceutical is active against sigma non-opioid intracellular receptor 1. In addition, it is known to target kappa-type opioid receptor, mu-type opioid receptor, and delta-type opioid receptor.
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SARS-CoV-2 Interaction
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
+
Pentazocine hydrochloride
Tradename
Company
Number
Date
Products
TALACENSanofiN-018458 DISCN1982-09-23
1 products
Hide discontinued
Aspirin
+
Pentazocine hydrochloride
Tradename
Company
Number
Date
Products
TALWIN COMPOUNDSanofiN-016891 DISCN1982-01-01
1 products, RLD
Hide discontinued
Naloxone hydrochloride
+
Pentazocine hydrochloride
Tradename
Company
Number
Date
Products
TALWIN NXSanofiN-018733 DISCN1982-12-16
1 products
Hide discontinued
Pentazocine hydrochloride
Tradename
Company
Number
Date
Products
TALWIN 50SanofiN-016732 DISCN1982-01-01
1 products
Hide discontinued
Pentazocine lactate
Tradename
Company
Number
Date
Products
TALWINHospiraN-016194 DISCN1982-01-01
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
pentazocine hydrochloride and naloxone hydrochlorideANDA2021-12-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AD: Benzomorphan derivative analgesics
— N02AD01: Pentazocine
HCPCS
Code
Description
J3070
Injection, pentazocine, 30 mg
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnesthesiaD000758———1—1
Induced abortionD000028———1—1
PainD010146EFO_0003843R52———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9—2———2
ManiaD000087122F30—1———1
Psychotic disordersD011618F20.81—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Labor painD048949————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePENTAZOCINE
INNpentazocine
Description
Pentazocine is a benzazocine.
Classification
Small molecule
Drug classnarcotic antagonists/agonists (6,7-benzomorphan derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)=CCN1CCC2(C)c3cc(O)ccc3CC1C2C
Identifiers
PDB6DK1
CAS-ID359-83-1
RxCUI8001
ChEMBL IDCHEMBL100116
ChEBI ID—
PubChem CID441278
DrugBankDB00652
UNII IDRP4A60D26L (ChemIDplus, GSRS)
Target
Agency Approved
SIGMAR1
SIGMAR1
Organism
Homo sapiens
Gene name
SIGMAR1
Gene synonyms
OPRS1, SRBP
NCBI Gene ID
10280
Protein name
sigma non-opioid intracellular receptor 1
Protein synonyms
Aging-associated gene 8 protein, hSigmaR1, SIG-1R, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R, SR-BP, SR31747 binding protein 1, SR31747-binding protein
Uniprot ID
Q99720
Mouse ortholog
Sigmar1 (18391)
sigma non-opioid intracellular receptor 1 (O55242)
Alternate
OPRK1
OPRK1
OPRM1
OPRM1
OPRD1
OPRD1
Organism
Homo sapiens
Gene name
OPRK1
Gene synonyms
OPRK
NCBI Gene ID
4986
Protein name
kappa-type opioid receptor
Protein synonyms
kappa opioid receptor, Opiate receptor, kappa-1
Uniprot ID
Q499G4
Mouse ortholog
Oprk1 (18387)
kappa-type opioid receptor (P33534)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,864 documents
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Safety
Black-box Warning
Black-box warning for: Pentazocine hydrochloride and naloxone hydrochloride
Adverse Events
Top Adverse Reactions
Mock data
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187 adverse events reported
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