Pentoxifylline
Pentoxil, Trental (pentoxifylline) is a small molecule pharmaceutical. Pentoxifylline was first approved as Trental on 1984-08-30. It is used to treat brain ischemia, cerebral malaria, diabetic angiopathies, diabetic neuropathies, and gangrene amongst others in the USA. It is known to target adenosine receptor A2b and cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
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Drug Products
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pentoxifylline
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRENTAL | Validus Pharmaceuticals | N-018631 DISCN | 1984-08-30 | 1 products, RLD |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| pentoxifylline | ANDA | 2023-05-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| brain ischemia | HP_0002637 | D002545 | I67.82 |
| cerebral malaria | — | D016779 | B50.0 |
| diabetic angiopathies | EFO_1000896 | D003925 | — |
| diabetic neuropathies | EFO_1000783 | D003929 | — |
| gangrene | EFO_0008574 | D005734 | R02 |
| intermittent claudication | EFO_0003876 | D007383 | I73.9 |
| stroke | EFO_0000712 | D020521 | I63.9 |
| thrombosis | — | D013927 | — |
| vasculitis | EFO_0006803 | D014657 | M31 |
| vasculogenic impotence | EFO_1001234 | D018783 | — |
Agency Specific
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Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 1 | 7 | — | 10 | 20 |
| Pneumocystis pneumonia | D011020 | EFO_0007448 | B59 | 2 | 1 | 7 | — | 10 | 20 |
| Cutaneous leishmaniasis | D016773 | B55.1 | — | 3 | 1 | — | — | 3 | |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | — | 1 | 1 | — | — | 1 |
| Visceral leishmaniasis | D007898 | B55.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | 1 | 2 | — | — | — | 2 | ||
| Lymphoma | D008223 | C85.9 | — | 1 | — | — | — | 1 | |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | — | 1 |
| Kidney transplantation | D016030 | 1 | 1 | — | — | — | 1 | ||
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Hypertrophic cicatrix | D017439 | L91.0 | 1 | 1 | — | — | — | 1 | |
| Non-small-cell lung carcinoma | D002289 | — | 1 | — | — | — | 1 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
| African trypanosomiasis | D014353 | B56 | — | 1 | — | — | — | 1 | |
| Melanoma | D008545 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin disease | D006689 | C81 | 1 | — | — | — | — | 1 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PENTOXIFYLLINE |
| INN | pentoxifylline |
| Description | Pentoxifylline is an oxopurine. |
| Classification | Small molecule |
| Drug class | theophylline derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O |
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Safety
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612 adverse events reported
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